Rabbit Polyclonal TMEM239(N-term) Antibody

The TMEM239 (N-term) antibody is a research tool designed to target the N-terminal region of transmembrane protein 239 (TMEM239), a poorly characterized protein encoded by the TMEM239 gene. TMEM239 belongs to the transmembrane protein family, which is implicated in diverse cellular processes, though its specific biological functions remain unclear. Preliminary studies suggest potential roles in cellular signaling, membrane trafficking, or organelle organization, but further validation is required. The antibody is commonly generated in hosts like rabbits or mice using synthetic peptides or recombinant protein fragments corresponding to the N-terminal epitopes of human TMEM239. It is typically validated for applications such as Western blotting, immunofluorescence, and immunohistochemistry to detect endogenous TMEM239 expression in cell lines or tissue samples. Specificity is often confirmed via knockout controls or siRNA-mediated gene silencing. Researchers utilize this antibody to explore TMEM239's localization, expression patterns, and interactions in contexts like cancer, neurodegenerative diseases, or metabolic disorders, where TMEM239 may serve as a biomarker or therapeutic target. Commercial versions often include detailed validation data (e.g., species reactivity, concentration, and batch-specific protocols). Optimal storage conditions usually involve -20°C in glycerol-containing buffers to prevent repeated freeze-thaw cycles. As TMEM239 research is still emerging, this antibody aids in elucidating its molecular mechanisms and pathophysiological relevance.