关键信息
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基因名
KIF1A
- 应用
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别名
KIF1A；ATSV；C2orf20；Kinesin-like Protein KIF1A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q12756
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
KIF1A, a member of the kinesin superfamily of motor proteins, plays a crucial role in intracellular transport, particularly in the anterograde movement of organelles and vesicles along microtubules. Recent studies have highlighted the significance of KIF1A in neuronal function, as mutations in the KIF1A gene have been linked to various neurodevelopmental disorders, including intellectual disability and autism spectrum disorders. Understanding the structure and function of KIF1A is essential for unraveling its biological roles and the mechanistic pathways involved in these diseases. Research into KIF1A recombinant protein aims to elucidate its motor activity, binding interactions, and regulatory mechanisms. By generating and characterizing recombinant KIF1A, scientists can probe its interactions with other cellular components, such as microtubules and cargo proteins, providing insights into its role in cellular transport mechanisms. Moreover, the development of KIF1A-based assays may facilitate the screening of potential therapeutic compounds aimed at ameliorating the functional deficits associated with KIF1A mutations. This ongoing research not only enhances our understanding of the fundamental processes governing cellular transport but also holds promise for therapeutic advancements in the treatment of KIF1A-related disorders, emphasizing the protein's emerging significance in biomedical science.
