| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Beta-defensin 107, Beta-defensin 7, BD-7, DEFB-7, Defensin, beta 107, DEFB107A, DEFB107, DEFB7 |
| Entrez GeneID | 245910;503614 |
| WB Predicted band size | 7.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This DEFB107A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 56-90 amino acids from the C-terminal region of human DEFB107A. |
+ +
以下是关于DEFB107A抗体的模拟参考文献示例(实际文献需通过学术数据库验证)：
1. **文献名称**: *"DEFB107A as a potential biomarker in human reproductive tract immunity"*
**作者**: Smith J, et al.
**摘要**: 该研究通过制备特异性抗DEFB107A的多克隆抗体，分析了其在人类生殖道上皮中的表达模式，发现DEFB107A蛋白与局部抗菌活性相关，提示其在黏膜免疫防御中的作用。
2. **文献名称**: *"Antibody-based detection of DEFB107A in inflammatory skin diseases"*
**作者**: Lee S, et al.
**摘要**: 研究利用单克隆抗体通过免疫组化技术检测DEFB107A在银屑病和湿疹患者皮肤中的表达，发现其表达水平与炎症程度呈正相关，可能参与皮肤屏障功能的调节。
3. **文献名称**: *"Structural characterization of DEFB107A using monoclonal antibodies"*
**作者**: Zhang Y, et al.
**摘要**: 通过开发高亲和力单克隆抗体，结合X射线晶体学分析，揭示了DEFB107A的三维结构及其抗菌功能域，为靶向药物设计提供了依据。
4. **文献名称**: *"DEFB107A antibody neutralization suppresses viral entry in vitro"*
**作者**: Kumar R, et al.
**摘要**: 研究显示，针对DEFB107A的抗体可通过阻断其与HIV病毒颗粒的结合，抑制病毒对宿主细胞的入侵，提示DEFB107A可能参与抗病毒免疫机制。
---
**注意**：以上为模拟生成的示例，真实文献需通过PubMed、Google Scholar等平台检索关键词(如“DEFB107A antibody”、“DEFB107A function”)获取。建议结合具体研究需求筛选近年高质量论文。
The DEFB107A antibody targets human beta-defensin 107A (DEFB107A), a member of the β-defensin family of small, cysteine-rich antimicrobial peptides. These peptides play critical roles in innate immunity, exhibiting broad-spectrum antimicrobial activity against bacteria, viruses, and fungi. DEFB107A is encoded by the DEFB107A gene, located in a defensin cluster on chromosome 8p23.1. It is primarily expressed in epithelial tissues, including the skin, respiratory tract, and reproductive organs, where it contributes to mucosal defense and immune modulation.
Research on DEFB107A has highlighted its potential involvement in host-pathogen interactions, wound healing, and inflammatory responses. Studies suggest it may also regulate cellular processes, such as chemotaxis and cytokine production, by interacting with specific receptors like CCR6. The DEFB107A antibody is a vital tool for investigating its expression patterns, localization, and functional mechanisms in both physiological and pathological contexts.
Commercially available DEFB107A antibodies are typically developed in rabbit or mouse hosts using synthetic peptides or recombinant proteins as immunogens. They are validated for applications such as immunohistochemistry, Western blotting, and ELISA. Recent studies utilizing these antibodies have explored DEFB107A's role in diseases like chronic inflammation, infections, and cancer, where its dysregulation may serve as a biomarker or therapeutic target. However, functional redundancy within the defensin family and tissue-specific expression patterns necessitate careful experimental design when interpreting results.
×
