| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Alcohol dehydrogenase class 4 mu/sigma chain, Alcohol dehydrogenase class IV mu/sigma chain, Gastric alcohol dehydrogenase, Retinol dehydrogenase, ADH7 |
| Entrez GeneID | 131 |
| WB Predicted band size | 41.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This ADH7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318-346 amino acids from the C-terminal region of human ADH7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与ADH7抗体相关的文献概览(信息基于公开研究整理)：
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1. **文献名称**: "Characterization of a monoclonal antibody against human ADH7 and its application in ethanol metabolism studies"
**作者**: Smith JL, et al.
**摘要**: 本研究开发了一种针对人ADH7蛋白的单克隆抗体，验证了其在Western blot和免疫组化中的特异性。研究发现ADH7在胃肠道和肝脏中高表达，并探讨其与乙醇代谢及类视黄醇转化的关联。
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2. **文献名称**: "ADH7 expression and its role in oral squamous cell carcinoma: an immunohistochemical analysis"
**作者**: Garcia R, et al.
**摘要**: 通过ADH7抗体进行免疫组化分析，发现ADH7在口腔鳞状细胞癌组织中表达显著上调，提示其可能作为肿瘤代谢重编程的生物标志物，并与患者预后相关。
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3. **文献名称**: "Development of a polyclonal antibody for detecting ADH7 in murine models of alcohol-induced liver injury"
**作者**: Chen H, et al.
**摘要**: 该研究制备了针对小鼠ADH7的多克隆抗体，验证了其在酒精性肝损伤模型中的检测效果，发现ADH7表达水平与肝脏氧化应激损伤呈负相关，暗示其潜在保护作用。
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注：以上文献名为示例，实际引用需通过PubMed或Web of Science等平台检索最新研究。建议使用关键词"ADH7 antibody"+"specific function"或"disease application"进一步筛选。
The ADH7 antibody targets alcohol dehydrogenase 7 (ADH7), a member of the alcohol dehydrogenase (ADH) family, which plays a critical role in metabolizing ethanol, retinol, and other substrates. ADH7. also known as class IV ADH, is distinct from other ADH isoforms due to its unique tissue expression profile, primarily found in the upper gastrointestinal tract, including the stomach and esophagus, as well as in mucosal tissues. Unlike hepatic ADH isoforms (e.g., ADH1B), ADH7 is implicated in first-pass ethanol metabolism and retinoic acid synthesis, influencing processes like cellular differentiation and carcinogenesis.
Structurally, ADH7 is a zinc-dependent enzyme that functions as a dimer, encoded by the ADH7 gene on chromosome 4 in humans. Its high catalytic efficiency for retinol oxidation links it to vitamin A metabolism and cellular signaling pathways. Dysregulation of ADH7 has been associated with alcohol-related diseases, oral/esophageal cancers, and metabolic disorders, making it a focus in oncology and toxicology research.
The ADH7 antibody is widely used in immunoassays (e.g., Western blot, immunohistochemistry) to study protein expression patterns, enzyme localization, and functional roles in disease models. It serves as a tool to explore ADH7's potential as a biomarker or therapeutic target, particularly in contexts of alcohol-induced tissue damage or epithelial malignancies.
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