| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Growth arrest and DNA damage-inducible proteins-interacting protein 1, 39S ribosomal protein L59, mitochondrial, MRP-L59, CKII beta-associating protein, CR6-interacting factor 1, CRIF1, Papillomavirus L2-interacting nuclear protein 1, PLINP, PLINP-1, p53-responsive gene 6 protein, GADD45GIP1, MRPL59, PLINP1, PRG6 |
| Entrez GeneID | 90480 |
| WB Predicted band size | 25.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GADD45GIP1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 13-45 amino acids from the N-terminal region of human GADD45GIP1. |
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以下是关于 **GADD45GIP1 (N-term)抗体** 的3篇示例文献(内容为虚构，仅供格式参考)：
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1. **文献名称**：*GADD45GIP1 interacts with CDK1 and regulates cell cycle progression in response to DNA damage*
**作者**：Zhang L, et al.
**摘要**：本研究利用GADD45GIP1 (N-term)特异性抗体进行免疫共沉淀(Co-IP)实验，发现GADD45GIP1在DNA损伤后与CDK1直接结合，抑制其激酶活性，从而阻滞细胞周期G2/M期转换。Western blot分析进一步证实了该相互作用在多种癌细胞系中的普遍性。
2. **文献名称**：*Expression profiling of GADD45GIP1 in colorectal cancer using a novel N-terminal antibody*
**作者**：Wang Y, et al.
**摘要**：通过GADD45GIP1 (N-term)抗体的免疫组化(IHC)分析，发现GADD45GIP1在结直肠癌组织中表达显著下调，且低表达与患者预后不良相关。体外实验表明，过表达GADD45GIP1可抑制癌细胞增殖并诱导凋亡。
3. **文献名称**：*The role of GADD45GIP1 in oxidative stress response: Insights from knockout models and antibody-based detection*
**作者**：Smith J, et al.
**摘要**：本研究利用GADD45GIP1 (N-term)抗体验证基因敲除小鼠模型中蛋白表达的缺失，并发现GADD45GIP1缺失导致细胞对氧化应激的敏感性增加。抗体特异性通过siRNA敲低实验及肽段竞争实验得到确认。
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如需真实文献，建议通过 **PubMed** 或 **Google Scholar** 检索关键词“GADD45GIP1 antibody”或“GADD45GIP1 N-terminal”。
The GADD45GIP1 (N-term) antibody is designed to target the N-terminal region of the GADD45 Gamma-Interacting Protein 1 (GADD45GIP1), a protein encoded by the *GADD45GIP1* gene. GADD45GIP1. also known as CRIF1 or CR6-interacting factor 1. plays critical roles in cellular stress responses, DNA repair, and cell cycle regulation. It interacts with members of the GADD45 family, particularly GADD45γ, to modulate pathways involved in apoptosis, genomic stability, and growth arrest. The N-terminal domain is essential for its interaction with partner proteins and regulatory functions, making it a key region for studying its biological activity.
This antibody is commonly used in research to detect and quantify endogenous GADD45GIP1 protein levels in various experimental models, including Western blotting, immunohistochemistry, and immunoprecipitation. Its specificity for the N-terminal epitope ensures minimal cross-reactivity with unrelated proteins, aiding in accurate analysis of GADD45GIP1 expression and localization under stress conditions, such as DNA damage or oxidative stress. Studies utilizing this antibody have contributed to understanding GADD45GIP1's role in diseases like cancer, neurodegenerative disorders, and metabolic syndromes, where dysregulation of stress-response pathways is implicated. Validation typically includes knockout cell line controls or peptide-blocking assays to confirm target specificity.
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