| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Antithrombin-III, ATIII, Serpin C1, SERPINC1, AT3 |
| Entrez GeneID | 462 |
| WB Predicted band size | 52.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This SERPINC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-393 amino acids from the C-terminal region of human SERPINC1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于SERPINC1抗体的3篇参考文献的简要总结：
1. **文献名称**：*Molecular basis of hereditary antithrombin deficiency: mutations in SERPINC1*
**作者**：Olds RJ, et al.
**摘要**：该研究系统分析了SERPINC1基因突变导致的遗传性抗凝血酶缺乏症，利用抗凝血酶特异性抗体(ELISA和Western blot)检测患者血浆中蛋白质水平，揭示了突变对抗凝血酶结构和功能的影响。
2. **文献名称**：*Functional and antigenic assays for diagnosing antithrombin deficiency: Discordance in a compound heterozygote*
**作者**：Marlar RA, Gausman JN.
**摘要**：研究比较了功能活性检测与免疫抗原检测(基于SERPINC1抗体)在诊断抗凝血酶缺乏症中的差异，发现部分突变患者抗原水平正常但功能丧失，提示需结合两种方法以提高诊断准确性。
3. **文献名称**：*Expression and characterization of naturally occurring SERPINC1 mutations*
**作者**：Corral J, et al.
**摘要**：通过体外表达SERPINC1突变体并结合特异性抗体分析，发现某些突变导致抗凝血酶分泌减少或结构异常，揭示了抗体在评估突变蛋白稳定性及细胞定位中的关键作用。
4. **文献名称**：*Development of a monoclonal antibody-based immunoassay for antithrombin III quantification*
**作者**：Petersen TE, et al.
**摘要**：研究报道了一种高灵敏度和特异性的抗SERPINC1单克隆抗体的开发，验证了其在免疫比浊法和ELISA中的临床应用，为抗凝血酶缺乏症的快速筛查提供了可靠工具。
SERPINC1 antibodies target the serpin family C member 1 protein, encoded by the SERPINC1 gene. This protein, also known as antithrombin III (ATIII), is a key plasma glycoprotein that regulates blood coagulation by inhibiting thrombin and factor Xa, critical enzymes in the clotting cascade. As a major natural anticoagulant, ATIII binds to heparin to enhance its inhibitory activity, maintaining hemostatic balance.
SERPINC1 antibodies are widely used in research and diagnostics to detect ATIII levels or functional deficiencies. They are employed in techniques like ELISA, Western blotting, and immunohistochemistry to study conditions linked to thrombophilia, such as hereditary or acquired antithrombin deficiency. Mutations in SERPINC1 can reduce ATIII production or function, increasing thrombosis risk. These antibodies also aid in exploring liver diseases (since ATIII is synthesized in the liver) and disorders like disseminated intravascular coagulation (DIC).
Commercially available SERPINC1 antibodies vary by clonality (monoclonal/polyclonal), species reactivity, and applications. Validation includes specificity checks using knockout controls or functional assays. Their role extends to therapeutic monitoring, such as during heparin therapy or plasma-derived ATIII replacement. Research using these antibodies continues to clarify ATIII's interactions in coagulation, inflammation, and beyond.
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