| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | F-box/LRR-repeat protein 17, F-box and leucine-rich repeat protein 17, F-box only protein 13, FBXL17, FBL17, FBX13, FBXO13 |
| Entrez GeneID | 64839 |
| WB Predicted band size | 75.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This FBXL17 Isoform 2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 262-297 amino acids from the C-terminal region of human FBXL17 Isoform 2. |
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以下是为您整理的3篇关于FBXL17 Isoform 2抗体的虚构参考文献，供参考：
1. **"Isoform-Specific Antibodies Reveal Distinct Roles of FBXL17 Variants in Ubiquitination"**
*作者：Chen et al.*
摘要：本研究开发了针对FBXL17不同剪接变体(包括Isoform 2)的特异性抗体，验证了其通过免疫沉淀和Western blot检测的可靠性，并发现Isoform 2在调控Wnt信号通路中具有独特作用。
2. **"FBXL17 Splice Variant 2 Promotes Tumor Metastasis via EGFR Degradation"**
*作者：Wang et al.*
摘要：通过使用Isoform 2特异性抗体，作者发现该变体在肺癌组织中高表达，并通过泛素化降解EGFR蛋白，揭示了其作为癌症治疗潜在靶点的机制。
3. **"Antibody-Based Profiling of F-Box Protein Isoforms in Neural Development"**
*作者：Kimura et al.*
摘要：文章评估了多种F-box蛋白抗体的交叉反应性，包括FBXL17 Isoform 2抗体，证实其在脑组织中的特异性，并发现该变体与神经突触可塑性相关。
**备注**：实际研究中，针对特定异构体的抗体文献可能较少，建议结合抗体供应商(如Abcam、CST)的产品说明书及引用文献，或扩大检索范围至FBXL17功能研究(部分文献可能隐含使用Isoform 2抗体)。若需真实文献，可进一步筛查PubMed或联系相关领域研究者获取未公开数据。
The FBXL17 (F-box and leucine-rich repeat protein 17) Isoform 2 antibody is a tool designed to specifically detect the second splice variant of the FBXL17 protein, a member of the F-box protein family. FBXL17 functions as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which targets specific proteins for ubiquitination and subsequent degradation via the proteasome. Isoform 2 arises from alternative splicing of the FBXL17 gene, potentially differing from other isoforms in its N- or C-terminal domains, which may influence substrate binding or protein-protein interactions.
This antibody is commonly used in research to investigate the expression, localization, and functional roles of FBXL17 Isoform 2 in cellular processes such as cell cycle regulation, signal transduction, and protein homeostasis. It is validated for applications including Western blotting, immunofluorescence, and immunohistochemistry, often in studies exploring cancer, neurological disorders, or developmental biology, where dysregulation of ubiquitination pathways is implicated. Specificity is confirmed through knockdown/knockout controls or isoform-selective assays to ensure minimal cross-reactivity with other FBXL17 variants. Researchers rely on this antibody to elucidate isoform-specific contributions to disease mechanisms or cellular physiology, making it a critical reagent in molecular and translational studies.
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