| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 175, Zinc finger protein OTK18, ZNF175 |
| Entrez GeneID | 7728 |
| WB Predicted band size | 81.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF175 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 150-187 amino acids from the N-terminal region of human ZNF175. |
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以下是关于ZNF175(N-term)抗体的示例参考文献(注：具体文献可能需要通过学术数据库验证，以下为基于研究背景的模拟示例)：
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1. **文献名称**: *"ZNF175 as a novel tumor suppressor in hepatocellular carcinoma through regulating EMT pathway"*
**作者**: Li X, et al.
**摘要**: 该研究报道ZNF175在肝细胞癌中通过抑制上皮-间质转化(EMT)发挥抑癌作用，使用ZNF175(N-term)抗体进行Western blot和免疫组化，证实其蛋白表达在癌组织中显著下调，且与患者预后相关。
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2. **文献名称**: *"Epigenetic silencing of ZNF175 promotes lung cancer progression via p53 signaling dysregulation"*
**作者**: Wang Y, et al.
**摘要**: 研究揭示ZNF175启动子区高甲基化导致其表达沉默，通过ZNF175(N-term)抗体检测发现其低表达与肺癌转移相关，并证实ZNF175通过调控p53通路抑制肿瘤生长。
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3. **文献名称**: *"Characterization of ZNF175 antibody specificity and its role in DNA damage response"*
**作者**: Chen H, et al.
**摘要**: 本文验证了ZNF175(N-term)抗体的特异性，证明其适用于免疫沉淀(IP)和免疫荧光，并发现ZNF175参与DNA损伤修复过程，与ATM激酶活性相关。
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4. **文献名称**: *"ZNF175 interacts with HDAC1 to modulate gene transcription in prostate cancer"*
**作者**: Zhang R, et al.
**摘要**: 研究发现ZNF175与组蛋白去乙酰化酶HDAC1相互作用，利用ZNF175(N-term)抗体进行ChIP实验，证实其靶向结合特定基因启动子区域，调控前列腺癌细胞的增殖。
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**提示**：以上文献为示例，建议通过PubMed、Google Scholar等平台，以关键词“ZNF175 antibody”“ZNF175 N-terminal”检索最新研究。部分抗体应用细节可能存在于公司技术文档(如Thermo Fisher、Abcam等产品说明书)。
The ZNF175 (N-term) antibody is designed to target the N-terminal region of the Zinc Finger Protein 175 (ZNF175), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. ZNF175 is encoded by the ZNF175 gene in humans and is implicated in transcriptional regulation, potentially through interactions with chromatin-modifying complexes. The KRAB domain at the N-terminus is critical for mediating protein-protein interactions, often serving as a repression domain by recruiting co-repressors like KAP1/TIF1β to facilitate heterochromatin formation and gene silencing.
This antibody is commonly used in research to study ZNF175's expression, localization, and function in cellular processes, including differentiation, apoptosis, and DNA damage response. It is validated for applications such as Western blotting, immunofluorescence, and immunoprecipitation, providing specificity for detecting endogenous ZNF175 protein in human or model organism samples. Studies suggest ZNF175 may play roles in tumor suppression, neurological disorders, or stem cell regulation, though its precise mechanisms remain under investigation. Researchers utilize this antibody to explore its involvement in diseases linked to chromatin remodeling defects or zinc finger protein dysregulation. Proper controls (e.g., knockout cell lines) are recommended to confirm signal specificity due to potential cross-reactivity with structurally similar zinc finger proteins.
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