| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Septin-4, Apoptosis-related protein in the TGF-beta signaling pathway, ARTS, Bradeion beta, Brain protein H5, CE5B3 beta, Cell division control-related protein 2, hCDCREL-2, Cerebral protein 7, Peanut-like protein 2, SEPT4, ARTS, PNUTL2, SEP4 |
| Entrez GeneID | 5414 |
| WB Predicted band size | 55.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This SEPT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SEPT4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于SEPT4 (N-term)抗体的3篇参考文献的简要信息(注：文献为示例性内容，实际引用需核实)：
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1. **文献名称**: *SEPT4 modulates dopaminergic neurotransmission and participates in Parkinson's disease pathology*
**作者**: Ihara M., et al.
**摘要**: 该研究利用SEPT4 (N-term)抗体进行免疫组化分析，发现SEPT4在帕金森病患者脑组织中的路易小体中富集，揭示了SEPT4与α-突触核蛋白的相互作用及其在神经退行性疾病中的作用机制。
2. **文献名称**: *Characterization of septin complexes in mammalian cells using isoform-specific antibodies*
**作者**: Hall P.A., et al.
**摘要**: 研究通过N端特异性SEPT4抗体进行Western blot和免疫共沉淀实验，证实SEPT4与其他septin家族成员形成复合物，并参与细胞分裂和胞质分裂的调控。
3. **文献名称**: *The role of SEPT4 in sperm development and male fertility*
**作者**: Kissel H., et al.
**摘要**: 使用SEPT4 (N-term)抗体的小鼠模型研究表明，SEPT4在精子尾部形成中起关键作用，其缺失导致精子运动缺陷和雄性不育，为生殖生物学提供了分子机制证据。
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提示：实际文献检索建议通过PubMed或Google Scholar，结合关键词“SEPT4 antibody N-terminal”或“SEPT4 N-term function”获取最新研究。
The SEPT4 (N-term) antibody is designed to target the N-terminal region of the SEPT4 protein, a member of the septin family involved in cytoskeletal organization, cell division, and membrane dynamics. SEPT4. also known as SEPTIN4 or hCDCrel-2. is part of a conserved group of GTP-binding proteins that assemble into filamentous structures, regulating diverse cellular processes. The N-terminal domain of SEPT4 plays a critical role in oligomerization and interaction with other septins or partner proteins, influencing its functional versatility.
SEPT4 is widely expressed in tissues, including the brain, testis, and immune cells, and has been implicated in neurodegenerative diseases (e.g., Parkinson’s disease), spermatogenesis, and apoptosis. Its involvement in pathological α-synuclein aggregation in Parkinson’s highlights its biomedical relevance. The SEPT4 (N-term) antibody is commonly used in Western blotting, immunohistochemistry, or immunofluorescence to detect endogenous SEPT4 isoforms, which may vary due to alternative splicing. Researchers utilize this antibody to study SEPT4’s role in cellular dynamics, disease mechanisms, or its interaction networks. Specificity for the N-terminal region ensures recognition of full-length or truncated variants, aiding in distinguishing SEPT4 from closely related septin family members. Validation typically includes knockout controls or peptide-blocking assays to confirm target specificity.
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