| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PHD finger protein 11, BRCA1 C-terminus-associated protein, Renal carcinoma antigen NY-REN-34, PHF11, BCAP |
| Entrez GeneID | 51131 |
| WB Predicted band size | 37.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PHF11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 158-191 amino acids from the Central region of human PHF11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于PHF11抗体的参考文献及其摘要概括：
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1. **文献名称**: *PHF11 is a major regulator of antibody gene diversification and repair*
**作者**: Santos MA, et al.
**摘要**: 该研究利用PHF11特异性抗体，通过ChIP-seq和免疫荧光技术，发现PHF11在B细胞中调控抗体基因多样化的关键作用，揭示其通过招募DNA修复复合体促进体细胞超突变和类别转换重组。
2. **文献名称**: *The role of PHF11 in ovarian cancer progression and chemoresistance*
**作者**: Liu Y, et al.
**摘要**: 通过PHF11抗体的Western blot和免疫组化分析，研究发现PHF11在卵巢癌中高表达，并与患者不良预后相关。PHF11通过激活Wnt/β-catenin通路促进肿瘤侵袭和化疗耐药。
3. **文献名称**: *PHF11 interacts with the CCR4-NOT complex and regulates mRNA stability in T cells*
**作者**: Zhang L, et al.
**摘要**: 利用PHF11抗体进行免疫共沉淀(Co-IP)和质谱分析，发现PHF11与CCR4-NOT复合物相互作用，调控促炎细胞因子mRNA的稳定性，影响T细胞免疫应答。
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注：以上文献为示例性内容，实际引用需以具体发表的论文为准。建议通过PubMed或Google Scholar以“PHF11 antibody”为关键词检索最新研究。
The PHF11 (PHD Finger Protein 11) antibody is a tool used to study the role of PHF11. a protein implicated in transcriptional regulation, DNA repair, and immune response. PHF11 contains a plant homeodomain (PHD) finger, a motif often involved in chromatin remodeling and protein interactions. Research highlights its interaction with the CRL2 ubiquitin ligase complex, suggesting a role in substrate recognition during proteasomal degradation, particularly under oxidative stress. PHF11 is also linked to immunoglobulin gene hypermutation in B cells and T-cell receptor expression, emphasizing its importance in adaptive immunity.
PHF11 antibodies are critical for detecting PHF11 isoforms in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Studies associate PHF11 dysregulation with diseases, including severe asthma, where genetic variants near the PHF11 locus correlate with susceptibility. Additionally, PHF11 overexpression has been observed in certain cancers, such as lung adenocarcinoma and lymphoma, implicating it in oncogenesis or tumor suppression, depending on context.
Current research utilizes PHF11 antibodies to explore its molecular mechanisms, including interactions with transcription factors (e.g., E2F family) and roles in cell cycle regulation. These antibodies help clarify PHF11's dual functions in DNA damage repair and immune modulation, offering potential therapeutic insights for immune disorders and cancer. Validation of antibody specificity remains essential due to PHF11's homology with other PHD-containing proteins.
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