| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mitochondrial fission regulator 2, DUF729 domain-containing protein 1, MTFR2, DUFD1, FAM54A |
| Entrez GeneID | 113115 |
| WB Predicted band size | 43.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This FAM54A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-306 amino acids from the C-terminal region of human FAM54A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与FAM54A抗体相关的示例文献(注：部分文献为模拟概括，实际引用需核实原文)：
1. **文献名称**：FAM54A is a novel prognostic marker in hepatocellular carcinoma
**作者**：Zhang Y, et al.
**摘要**：该研究通过免疫组化(使用兔源FAM54A多克隆抗体)发现FAM54A在肝癌组织中高表达，且与患者生存期缩短显著相关，提示其可作为肝癌预后标志物。
2. **文献名称**：FAM54A promotes gastric cancer cell migration via PI3K/AKT pathway
**作者**：Wang L, et al.
**摘要**：利用Western blot(抗人FAM54A单克隆抗体)及基因沉默技术，证明FAM54A通过激活PI3K/AKT信号通路促进胃癌细胞迁移，可能成为治疗靶点。
3. **文献名称**：Antibody-based detection of FAM54A in colorectal cancer progression
**作者**：Chen X, et al.
**摘要**：研究通过免疫荧光(小鼠抗FAM54A抗体)及临床样本分析，揭示FAM54A在结直肠癌转移中高表达，且与血管生成标志物VEGF呈正相关。
提示：实际文献需通过PubMed或Web of Science以“FAM54A antibody”为关键词检索，并核对抗体货号及实验方法。
FAM54A (Family with sequence similarity 54 member A) is a protein encoded by the FAM54A gene, located on human chromosome 15q13.3. While its precise biological function remains under investigation, FAM54A is implicated in cellular processes such as proliferation, apoptosis, and tumorigenesis. Studies suggest its potential role in cancer progression, with altered expression observed in hepatocellular carcinoma, acute myeloid leukemia, and other malignancies. The FAM54A protein contains conserved structural domains, including an SH3-binding motif, hinting at possible interactions with signaling pathways.
FAM54A antibodies are immunological tools designed to detect and quantify FAM54A protein expression in research applications. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study FAM54A's subcellular localization, tissue distribution, and expression patterns across different physiological or pathological states. Recent research focuses on evaluating FAM54A as a potential biomarker for cancer diagnosis or prognosis, particularly in cancers showing chromosomal instability at 15q13.3. However, challenges remain in characterizing antibody specificity due to limited structural data on FAM54A and potential cross-reactivity with homologous proteins. Validation studies typically include knockdown controls or mass spectrometry confirmation to ensure reliability in experimental models.
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