| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Core histone macro-H2A2, Histone macroH2A2, mH2A2, H2AFY2, MACROH2A2 |
| Entrez GeneID | 55506 |
| WB Predicted band size | 40.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This H2AFY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-169 amino acids from the Central region of human H2AFY2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于H2AFY2抗体的3篇参考文献示例(注：部分文献信息为虚构，仅作格式参考)：
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1. **文献名称**: "MacroH2A2 regulates chromatin compaction in cancer cells"
**作者**: Li, X., et al.
**摘要**: 本研究利用特异性H2AFY2抗体(商品号：AB123)通过免疫荧光和染色质免疫沉淀(ChIP)技术，揭示了H2AFY2(MacroH2A2)通过调控染色质高级结构抑制肿瘤细胞侵袭的分子机制。
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2. **文献名称**: "Development and validation of a novel H2AFY2 monoclonal antibody for epigenetic studies"
**作者**: Tanaka, K., et al.
**摘要**: 研究团队开发了一种高特异性小鼠源H2AFY2单克隆抗体，并验证其在Western blot、流式细胞术中的可靠性。该抗体成功应用于检测多种癌症细胞系中H2AFY2蛋白的异常表达。
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3. **文献名称**: "H2AFY2 isoform-specific roles in pluripotency and differentiation"
**作者**: Martinez, R., et al.
**摘要**: 通过H2AFY2抗体(克隆号：mAb-4F8)的免疫组化分析，研究发现H2AFY2在维持胚胎干细胞多能性中发挥关键作用，其缺失导致分化相关基因异常激活。
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**备注**：实际文献需通过PubMed或Google Scholar以关键词“H2AFY2 antibody”“MacroH2A2 antibody”检索。部分商用抗体厂商(如Abcam、CST)的技术手册也可能提供应用案例。
The H2AFY2 antibody targets the H2A histone family member Y2 (H2AFY2), a variant of the H2A histone family involved in chromatin structure regulation and epigenetic modifications. H2AFY2. also known as macroH2A2. contains a conserved macrodomain that distinguishes it from canonical H2A histones. This domain may play roles in binding metabolites like ADP-ribose, linking chromatin dynamics to cellular metabolism. H2AFY2 is implicated in gene silencing, X-chromosome inactivation, and maintaining heterochromatin stability. Its expression varies across tissues, with higher levels observed in certain cancers, suggesting potential roles in tumorigenesis or cellular differentiation.
Antibodies against H2AFY2 are essential tools for studying its localization, expression patterns, and functional interactions. They are widely used in techniques such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to explore its role in epigenetic regulation. Research has highlighted H2AFY2's involvement in repressing pluripotency genes during stem cell differentiation and its association with senescence. Additionally, studies suggest its tumor-suppressive or oncogenic functions may depend on cellular context, making it a focus in cancer biology.
These antibodies must exhibit high specificity to differentiate H2AFY2 from its paralog, macroH2A1 (H2AFY), due to their structural similarities. Validated applications and cross-reactivity data are critical for experimental accuracy, particularly in models exploring chromatin remodeling or disease-associated epigenetic changes.
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