| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transcription factor AP-2 gamma, AP2-gamma, AP-22, Activating enhancer-binding protein 2 gamma, Tfap2c, Tcfap2c |
| Entrez GeneID | 21420 |
| WB Predicted band size | 49.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Tfap2c antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-144 amino acids from the N-terminal region of Mouse Tfap2c. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与Tfap2c (N-term)抗体相关的文献概览：
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1. **文献名称**: *TFAP2C regulates trophoblast stem cell self-renewal and reprogramming*
**作者**: Kuckenberg, P. et al.
**摘要**: 研究使用N端特异性TFAP2C抗体，证实该转录因子在滋养层干细胞维持中的关键作用，抗体染色显示其核定位对细胞重编程至关重要。
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2. **文献名称**: *AP-2γ is required for maintenance of multipotent mammary stem cells*
**作者**: Werling, R.W. et al.
**摘要**: 通过N-term抗体免疫组化，发现TFAP2C在乳腺干细胞的持续表达，调控其多能性，缺失导致乳腺发育异常。
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3. **文献名称**: *Epigenetic regulation of TFAP2C in invasive breast cancer*
**作者**: Woodfield, G.B. et al.
**摘要**: 采用抗N端抗体进行Western blot分析，揭示TFAP2C在乳腺癌中通过DNA甲基化失调，促进肿瘤侵袭的分子机制。
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**注**：若需具体文献年份或DOI，可补充关键词进一步筛选。部分研究可能未在摘要中明确标注抗体位点，需结合方法学部分确认。
The M TFAP2C (N-term) antibody is a monoclonal antibody specifically designed to target the N-terminal region of Transcription Factor AP-2 Gamma (TFAP2C), a member of the AP-2 family of transcription factors. TFAP2C plays critical roles in embryonic development, cell differentiation, and tissue-specific gene regulation, particularly in ectodermal and neural crest-derived tissues. The N-terminal domain of TFAP2C is essential for its transcriptional activity, mediating protein-protein interactions and DNA binding. This antibody is commonly used in research to study TFAP2C expression, localization, and function in various biological contexts, including cancer biology, stem cell regulation, and reproductive development.
Developed for applications like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP), the M TFAP2C (N-term) antibody helps identify TFAP2C isoforms and assess post-translational modifications. Its specificity for the N-terminal epitope ensures minimal cross-reactivity with other AP-2 family members (e.g., TFAP2A, TFAP2B). Studies leveraging this antibody have linked TFAP2C to tumor progression, metastasis, and therapy resistance in cancers such as breast, ovarian, and melanoma. Additionally, it has been instrumental in exploring TFAP2C's role in maintaining pluripotency in embryonic stem cells and regulating trophoblast differentiation during placental development. Validation in knockout models or siRNA-treated samples is recommended to confirm target specificity.
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