| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Syntaxin-1B, Syntaxin-1B1, Syntaxin-1B2, STX1B, STX1B1, STX1B2 |
| Entrez GeneID | 112755 |
| WB Predicted band size | 33.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | This STX1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human STX1B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于STX1B (N-term)抗体的假设参考文献示例(注：以下内容为虚构，仅供格式参考)：
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1. **文献名称**: "Syntaxin-1B N-terminal antibody reveals dynamic localization in hippocampal neurons"
**作者**: Müller, A., et al.
**摘要**: 本研究利用STX1B (N-term)特异性抗体，通过免疫荧光技术观察了Syntaxin-1B蛋白在小鼠海马神经元中的亚细胞分布。结果表明，该蛋白在突触前膜呈动态聚集，并与突触小泡释放过程密切相关。
2. **文献名称**: "Characterization of STX1B antibody for detecting SNARE complex assembly"
**作者**: Chen, L., & Zhang, Y.
**摘要**: 通过Western blot和免疫共沉淀实验，验证了STX1B (N-term)抗体对SNARE复合体组装的检测能力。研究发现，该抗体能特异性识别天然构象的Syntaxin-1B，并成功应用于研究其与SNAP-25的相互作用。
3. **文献名称**: "STX1B N-term antibody identifies loss-of-function mutations in epilepsy models"
**作者**: Okabe, S., et al.
**摘要**: 在遗传性癫痫小鼠模型中，使用STX1B (N-term)抗体检测到Syntaxin-1B的蛋白表达量显著降低。实验提示，该抗体可作为STX1B功能缺失突变的生物标志物工具。
4. **文献名称**: "Comparative analysis of STX1B antibodies in neuronal tissue imaging"
**作者**: Gupta, R., et al.
**摘要**: 本研究评估了多种STX1B抗体的特异性，发现针对N端的抗体在石蜡包埋脑组织切片中表现出更高的信噪比，适用于病理学中突触蛋白异常的检测。
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(注意：上述文献为示例，实际引用请通过PubMed、Google Scholar等平台检索真实发表的研究。)
The STX1B (N-term) antibody targets the N-terminal region of syntaxin-1B (STX1B), a key protein involved in synaptic vesicle fusion and neurotransmitter release. STX1B is a member of the syntaxin family, which are core components of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex. This complex mediates the docking and fusion of synaptic vesicles with the presynaptic membrane, a critical step in exocytosis. STX1B is predominantly expressed in neuronal tissues and localizes to the plasma membrane, where it interacts with other SNARE proteins like SNAP-25 and synaptobrevin (VAMP) to facilitate membrane fusion.
Research on STX1B has highlighted its role in regulating synaptic transmission and plasticity. Mutations or dysregulation of STX1B have been linked to neurological disorders, including epilepsy and developmental encephalopathies. The N-terminal domain of STX1B is particularly important for its interaction with regulatory proteins, such as Munc18-1. which stabilizes syntaxin in a closed conformation and ensures proper SNARE assembly.
The STX1B (N-term) antibody is widely used in neuroscience research to study protein expression, localization, and interactions in neuronal cells or tissues. It is commonly applied in techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Validation typically includes testing in knockout models or siRNA-treated samples to confirm specificity. This antibody aids in elucidating the molecular mechanisms underlying synaptic function and dysfunction, contributing to advancements in understanding neurological diseases and potential therapeutic targets.
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