| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/25 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tumor protein D55, hD55, Testis development protein NYD-SP25, Tumor protein D52-like 3, TPD52L3 |
| Entrez GeneID | 89882 |
| WB Predicted band size | 15.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TPD52L3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-38 amino acids from the N-terminal region of human TPD52L3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是模拟生成的关于TPD52L3 (N-term)抗体的参考文献示例(非真实文献，仅供格式参考)：
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1. **文献名称**: "Characterization of TPD52L3 Expression in Prostate Cancer Using a Novel N-terminal Specific Antibody"
**作者**: Smith A, et al.
**摘要**: 研究开发了一种针对TPD52L3蛋白N端的高特异性抗体，通过Western blot和免疫组化验证其在前列腺癌组织中的表达上调，并探讨其与肿瘤进展的关系。
2. **文献名称**: "TPD52L3 Regulates Vesicle Trafficking via Interaction with Rab GTPases"
**作者**: Chen L, et al.
**摘要**: 利用N端抗体进行免疫共沉淀实验，发现TPD52L3通过N端结构域与Rab家族蛋白相互作用，调控细胞内囊泡运输机制。
3. **文献名称**: "Development and Validation of a TPD52L3 (N-term) Monoclonal Antibody for Immunofluorescence Staining"
**作者**: Wang Y, et al.
**摘要**: 报道了一种针对TPD52L3 N端的单克隆抗体的开发，验证其在细胞系中的亚细胞定位(如高尔基体和内体)，并用于乳腺癌细胞模型的功能研究。
4. **文献名称**: "TPD52L3 as a Potential Biomarker in Colorectal Cancer: Insights from Antibody-based Detection"
**作者**: Gupta R, et al.
**摘要**: 使用N端特异性抗体分析结直肠癌患者样本，发现TPD52L3的高表达与转移和不良预后显著相关，提示其作为治疗靶点的潜力。
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**注意**：以上文献为模拟生成，实际引用时需通过学术数据库(如PubMed、Web of Science)检索真实文献并核对信息。
The TPD52L3 (N-term) antibody targets the N-terminal region of Tumor Protein D52-Like 3 (TPD52L3), a member of the TPD52 family implicated in cell proliferation, apoptosis, and cancer progression. TPD52 family proteins share conserved coiled-coil domains and interact with signaling molecules, influencing vesicle trafficking, autophagy, and cell survival. TPD52L3. located on chromosome 19p13.3. is overexpressed in cancers like prostate, breast, and lung, correlating with tumor aggressiveness and poor prognosis.
The N-terminal-specific antibody detects endogenous TPD52L3 isoforms, aiding in studying its expression, localization, and interactions. It is widely used in Western blotting, immunohistochemistry, and immunofluorescence to investigate TPD52L3's role in oncogenic pathways, such as PI3K/AKT and ERK signaling. Researchers also utilize it to explore TPD52L3's involvement in exosome biogenesis and stress responses.
Developed using immunogenic peptides from the N-terminal region, this antibody’s specificity is validated through knockout controls or siRNA knockdown. Its applications extend to cancer biomarker studies and therapeutic target validation. Understanding TPD52L3 dynamics through this antibody contributes to insights into cellular adaptation mechanisms and potential clinical interventions.
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