Rabbit Polyclonal MTcfap2d Antibody

The MTcfap2d antibody is a tool used to detect the transcription factor AP-2δ (TFAP2D), a member of the AP-2 family of DNA-binding proteins. These evolutionarily conserved regulators play roles in embryonic development, cell differentiation, and tissue homeostasis. TFAP2D, encoded by the *TFAP2D* gene, is less characterized than other AP-2 isoforms (e.g., AP-2α or AP-2γ) but is implicated in neural development, craniofacial morphogenesis, and cancer progression. Studies suggest it may regulate gene networks in neural crest cells and influence neurotransmitter systems. The MTcfap2d antibody, typically raised in mice or rabbits, binds specifically to TFAP2D epitopes, enabling applications like Western blotting, immunohistochemistry, or chromatin immunoprecipitation. Its development has facilitated investigations into TFAP2D's nuclear localization, expression patterns in tissues like the brain or adrenal glands, and dysregulation in diseases such as neuroblastoma or breast cancer. However, challenges persist in verifying antibody specificity due to homology among AP-2 family members. Recent research using this antibody has explored TFAP2D's role in neurodevelopmental disorders and its potential as a biomarker. Proper validation with knockout controls remains critical for experimental reliability.