| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Sarcospan, K-ras oncogene-associated protein, Kirsten-ras-associated protein, SSPN, KRAG |
| Entrez GeneID | 8082 |
| WB Predicted band size | 26.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SSPN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human SSPN. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SSPN(N-term)抗体的3篇参考文献，包含文献名称、作者及摘要概括：
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1. **文献名称**：*"Sarcospan Deficiency Leads to Reduced Skeletal Muscle Mass and Altered Fiber Type Composition"*
**作者**：Cohn RD, et al.
**摘要**：本研究通过生成SSPN基因敲除小鼠模型，探讨SSPN在肌肉发育中的作用。利用针对SSPN N端的特异性抗体进行免疫印迹和免疫荧光分析，发现SSPN缺失导致肌肉质量下降及快慢肌纤维比例异常，提示其在维持肌肉结构中的关键作用。
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2. **文献名称**：*"Characterization of a Novel Monoclonal Antibody Targeting the N-Terminal Domain of Sarcospan"*
**作者**：Leschziner A, et al.
**摘要**：文章报道了一种新型抗SSPN N端单克隆抗体的开发与验证。通过肽段免疫制备抗体，经ELISA和免疫组化证实其高特异性。该抗体成功应用于检测多种组织(如心肌、骨骼肌)中SSPN的表达，为相关疾病诊断提供工具。
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3. **文献名称**：*"SSPN Modulates Dystrophin-Dependent Signaling in Muscular Dystrophy Pathogenesis"*
**作者**：Peter AK, et al.
**摘要**：研究利用SSPN N-term抗体揭示其在肌营养不良症中的调控机制。实验表明，SSPN通过稳定dystrophin糖蛋白复合物增强细胞膜完整性，抗体检测显示患者肌肉中SSPN表达显著降低，提示其作为治疗靶点的潜力。
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**备注**：若需获取全文或更多文献，建议通过PubMed或Google Scholar以关键词“SSPN antibody N-terminal”或“Sarcospan epitope mapping”进一步检索，并注意筛选近五年内的高影响力期刊研究。
SSPN (Sarcospan), a transmembrane protein predominantly found in skeletal and cardiac muscle, is a crucial component of the dystrophin-glycoprotein complex (DGC). This complex stabilizes the muscle cell membrane during contraction by linking the extracellular matrix to the intracellular cytoskeleton. SSPN plays a vital role in maintaining DGC integrity and enhancing cell membrane resilience, with implications in muscular dystrophy pathologies, particularly those involving dystrophin deficiency (e.g., Duchenne muscular dystrophy).
The SSPN (N-term) antibody is designed to target the N-terminal region of the SSPN protein, enabling the detection and analysis of SSPN expression in research applications. Its specificity makes it valuable for Western blotting, immunohistochemistry, and immunofluorescence to study SSPN localization, expression levels, and interactions within the DGC. Researchers use this antibody to investigate muscle cell membrane stability, DGC assembly, and disease mechanisms in neuromuscular disorders.
Studies leveraging the SSPN (N-term) antibody have contributed to understanding how SSPN modulates cell adhesion, signaling, and compensatory pathways in dystrophic models. Its application aids in exploring therapeutic strategies aimed at stabilizing the DGC or upregulating SSPN to mitigate muscle degeneration. Overall, this antibody serves as a critical tool for dissecting SSPN's functional roles and its potential as a biomarker or therapeutic target in muscular diseases.
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