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Rabbit Polyclonal MouseMast1 Antibody

  • 中文名: Mouse Mast1抗体
  • 别    名: Microtubule-associated serine/threonine-protein kinase 1, Syntrophin-associated serine/threonine-protein kinase, Mast1 {ECO:0000312|MGI:MGI:1861901}
货号: IPDX32461
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMicrotubule-associated serine/threonine-protein kinase 1, Syntrophin-associated serine/threonine-protein kinase, Mast1 {ECO:0000312|MGI:MGI:1861901}
Entrez GeneID56527
WB Predicted band size171.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis Mouse Mast1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1438-1464 amino acids from the C-terminal region of mouse Mast1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇关于Mouse Mast1抗体的示例文献(注:以下为假设性示例,具体文献需根据实际数据库检索验证):

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1. **文献名称**: "Mast1 regulates cortical neuron migration and synaptic plasticity in developing mouse brain"

**作者**: Smith A, et al.

**摘要**: 本研究通过Western blot和免疫组化技术,使用特异性Mouse Mast1抗体揭示Mast1蛋白在小鼠大脑皮层发育中的表达模式。结果表明,Mast1缺失导致神经元迁移障碍和突触功能异常,提示其在神经发育中的关键作用。

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2. **文献名称**: "Generation and characterization of a Mast1 knockout mouse model using CRISPR/Cas9"

**作者**: Johnson R, et al.

**摘要**: 作者开发了Mast1基因敲除小鼠,并通过Mouse Mast1抗体验证了蛋白表达的完全缺失。表型分析显示,Mast1敲除小鼠表现出运动协调缺陷和自闭症样行为,为研究Mast1相关神经疾病提供了模型。

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3. **文献名称**: "Antibody-based profiling of Mast1 expression in tumor microenvironment"

**作者**: Lee H, et al.

**摘要**: 该研究利用Mouse Mast1抗体对多种小鼠肿瘤模型的组织切片进行染色,发现Mast1在肿瘤相关巨噬细胞中高表达,且与肿瘤转移呈正相关,提示其作为癌症治疗靶点的潜力。

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如需真实文献,建议在PubMed或Web of Science中检索关键词:**"Mast1 antibody mouse"** 或 **"Mast1 knockout mouse"**,并筛选涉及抗体验证、蛋白功能或疾病模型的文章。

背景信息

The Mouse Mast1 (MAST1) antibody is a tool used to study the MAST1 protein, a microtubule-associated serine/threonine kinase encoded by the *MAST1* gene. MAST1 is primarily expressed in the nervous system and plays roles in neuronal signaling, cytoskeletal organization, and synaptic plasticity. Mutations in *MAST1* have been linked to neurodevelopmental disorders, including megalencephaly and intellectual disability. The antibody, typically raised in rabbits or mice, targets specific epitopes of the mouse MAST1 protein, enabling detection in techniques like Western blotting, immunohistochemistry, or immunofluorescence. It is crucial for investigating MAST1’s expression patterns, interactions (e.g., with the mTOR pathway), and dysfunction in disease models. Validation often includes testing in *Mast1* knockout tissues to confirm specificity. Research using this antibody has advanced understanding of MAST1’s role in neuronal development and pathology, offering insights into therapeutic targets for related disorders. Commercial versions may vary in clonality (monoclonal/polyclonal) and recommended applications, so verification against experimental needs is essential.

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