| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Raftlin, Cell migration-inducing gene 2 protein, Raft-linking protein, RFTN1, KIAA0084 |
| Entrez GeneID | 23180 |
| WB Predicted band size | 63.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This RFTN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-198 amino acids from the Central region of human RFTN1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及RFTN1抗体的研究文献摘要概述，按领域分类整理：
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1. **文献名称**：RFTN1 modulates mitochondrial energy metabolism in macrophages during bacterial infection
**作者**：Chen Y, et al. (2020)
**摘要内容**：该研究利用抗RFTN1抗体通过免疫共沉淀技术，揭示了RFTN1蛋白通过与线粒体复合物III相互作用调控巨噬细胞能量代谢的机制，为细菌感染中的免疫代谢研究提供了新视角。
2. **文献名称**：Aberrant RFTN1 expression correlates with axonal degeneration in Alzheimer's disease models
**作者**：Tanaka K, et al. (2018)
**摘要内容**：研究使用抗RFTN1抗体进行脑组织免疫组化分析，发现阿尔茨海默病模型小鼠皮层中RFTN1异常聚集与轴突退行性病变存在显著相关性，提示其可能参与tau蛋白病理进程。
3. **文献名称**：Development of monoclonal antibody against human RFTN1 for cancer biomarker screening
**作者**：Wang L, et al. (2021)
**摘要内容**：团队成功制备了针对人源RFTN1的单克隆抗体，通过ELISA和免疫印迹验证其特异性，并在乳腺癌组织芯片中检测到RFTN1表达水平与肿瘤转移潜能呈正相关，证实其作为潜在生物标志物的价值。
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**注**：以上文献为示例性内容，实际文献需通过PubMed或Web of Science等学术平台用关键词"RFTN1 AND (antibody OR immunohistochemistry)"检索验证。建议优先选择近3年发表的、影响因子>5的期刊文献进行参考。
The RFTN1 (Raftlin, Lipid Raft Protein 1) antibody is a research tool used to study the RFTN1 protein, a key component of lipid rafts—dynamic membrane microdomains involved in cellular signaling, trafficking, and adhesion. RFTN1 is highly expressed in immune cells, including B and T lymphocytes, and plays a critical role in organizing lipid raft structures, particularly during immune receptor signaling. It facilitates the assembly and stabilization of signaling complexes, impacting B-cell receptor (BCR) activation, T-cell responses, and inflammatory processes. Dysregulation of RFTN1 has been linked to immune disorders, cancers (e.g., lymphomas), and neurodegenerative conditions, highlighting its broader pathophysiological relevance.
Antibodies targeting RFTN1 enable researchers to detect and quantify its expression via techniques like Western blotting, immunohistochemistry, and flow cytometry. These tools help elucidate RFTN1’s spatial distribution, interaction partners, and functional roles in lipid raft-mediated signaling. Recent studies also explore its potential as a biomarker in diseases characterized by disrupted membrane dynamics. Despite progress, the precise molecular mechanisms of RFTN1 in health and disease remain under investigation, underscoring the continued importance of high-specificity RFTN1 antibodies in advancing cellular and immunological research.
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