Rabbit Polyclonal SGOL2 Antibody

The Shugoshin-like 2 (SGOL2) protein is a member of the shugoshin family, evolutionarily conserved proteins critical for protecting centromeric cohesin complexes during mitosis and meiosis. SGOL2 primarily ensures faithful chromosome segregation by preventing premature separation of sister chromatids, working in coordination with other regulatory proteins like PP2A phosphatase. It localizes to centromeres during early mitosis, safeguarding cohesion until anaphase onset. Dysregulation of SGOL2 is implicated in chromosomal instability, a hallmark of various cancers, and has been linked to tumor progression and poor prognosis. SGOL2 antibodies are essential tools for studying its expression, localization, and functional roles in cell cycle regulation. These antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate SGOL2's involvement in mitotic fidelity, cancer biology, and potential therapeutic targeting. Species-specific SGOL2 antibodies (e.g., human, mouse, rat) enable comparative studies across models. Research also explores SGOL2's non-canonical roles in cellular processes like DNA repair and apoptosis. Validated antibodies with high specificity are critical, as shugoshin family members share structural homology, necessitating careful epitope selection to avoid cross-reactivity.