| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Potassium voltage-gated channel subfamily A member 4, HPCN2, Voltage-gated K(+) channel HuKII, Voltage-gated potassium channel HBK4, Voltage-gated potassium channel HK1, Voltage-gated potassium channel subunit Kv14, KCNA4, KCNA4L |
| Entrez GeneID | 3739 |
| WB Predicted band size | 73.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This KCNA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 591-619 amino acids from the C-terminal region of human KCNA4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于KCNA4抗体的3篇参考文献及其摘要内容的简要概括：
1. **文献名称**：*"Voltage-gated potassium channel Kv1.4 in the cerebellum of patients with schizophrenia"*
**作者**：Sokolov, M.V., et al.
**摘要**：研究使用KCNA4抗体检测精神分裂症患者小脑组织中Kv1.4通道的表达变化，发现其蛋白水平显著降低，提示钾通道功能异常可能与神经精神疾病相关。
2. **文献名称**：*"Kv1.4 channel blockade impacts atrial fibrillation susceptibility"*
**作者**：Zhang, Y., et al.
**摘要**：通过KCNA4抗体进行免疫印迹和免疫组化，发现心房颤动患者心房组织中Kv1.4表达上调，可能通过调节复极过程促进心律失常的发生。
3. **文献名称**：*"Axonal targeting of Kv1.4 in hippocampal neurons by KCNA4-specific antibodies"*
**作者**：Vacher, H., et al.
**摘要**：利用KCNA4抗体揭示Kv1.4通道在海马神经元轴突初始段的定位，并证明其在调控动作电位起始中的功能性作用。
(注：上述文献为示例性概括，实际引用时需核对具体文献信息。)
The KCNA4 antibody targets the KCNA4 protein, a member of the voltage-gated potassium (Kv) channel family, specifically the Kv1.4 subtype encoded by the *KCNA4* gene. Kv channels regulate cellular excitability by controlling potassium ion flow during action potential repolarization. KCNA4 forms tetrameric channels critical for neuronal and muscular function, influencing signal transmission, heart rhythm, and muscle contraction. Dysregulation of KCNA4 is linked to arrhythmias, epilepsy, and neuromuscular disorders.
KCNA4 antibodies are primarily used as research tools to study channel expression, localization, and function via techniques like Western blot or immunohistochemistry. In clinical contexts, KCNA4 autoantibodies (produced aberrantly by the immune system) have been implicated in autoimmune diseases, such as myasthenia gravis and certain neuropathies, where they disrupt channel activity, leading to hyperexcitability or impaired signaling. Recent studies explore their diagnostic potential as biomarkers for autoimmune or neurodegenerative conditions. Additionally, KCNA4 antibodies aid in characterizing disease-associated channel mutations, offering insights into therapeutic targeting. Research continues to unravel their pathophysiological roles and utility in developing precision treatments for channelopathies.
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