Rabbit Polyclonal OR5W2(C-term) Antibody

The OR5W2 (C-term) antibody targets the C-terminal region of olfactory receptor 5W2. a G protein-coupled receptor (GPCR) involved in odorant detection. OR5W2 is part of the large olfactory receptor family, which mediates signal transduction in response to specific chemical stimuli, primarily in olfactory neurons. The C-terminal domain often contributes to receptor localization, intracellular signaling, or interaction with regulatory proteins. This antibody is used to study OR5W2’s expression, tissue distribution, and function through techniques like Western blotting, immunohistochemistry, or immunofluorescence. Due to high sequence conservation among olfactory receptors, specificity validation is essential; rigorous testing with knockout models or orthogonal methods is typically required to confirm minimal cross-reactivity. Research applications include exploring OR5W2’s role in olfaction, its potential expression in non-olfactory tissues (e.g., in disease contexts), or its regulatory mechanisms. However, challenges persist in distinguishing OR5W2 from closely related receptors, particularly in conserved regions like the C-terminus. Despite this, the antibody remains a key tool for deciphering OR5W2’s biological significance and its contribution to sensory or systemic processes. Researchers are advised to validate its performance in their specific experimental systems to ensure reliability. (Word count: 199)