Rabbit Polyclonal IL17RE(N-term) Antibody

中文名： IL17RE(N-term)抗体
别名： Interleukin-17 receptor E, IL-17 receptor E, IL-17RE, IL17RE

货号: IPDX32272

Price： ￥1180

50μl 100μl

数量：

大包装询价

验证与应用

应用及物种

WB	1/1000	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	咨询技术	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	咨询技术	Human,Mouse,Rat

产品详情

Aliases	Interleukin-17 receptor E, IL-17 receptor E, IL-17RE, IL17RE
Entrez GeneID	132014
WB Predicted band size	74.8kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This IL17RE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-116 amino acids from the N-terminal region of human IL17RE.
Formulation	Purified antibody in PBS with 0.05% sodium azide.

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IL17RE Antibody (N-term) (Cat. #P32272) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the IL17RE antibody detected the IL17RE protein (arrow).

参考文献

以下是关于IL17RE(N-term)抗体的3篇参考文献及其简要摘要：

1. **文献名称**：*IL-17 receptor signaling in the skin protects from metabolic dysfunction*

**作者**：Blanco, D.B., et al.

**摘要**：该研究使用IL17RE(N-term)抗体检测皮肤中IL-17RE的表达，发现其在调控皮肤屏障功能和代谢炎症中的关键作用，揭示了IL-17信号通路与代谢疾病的潜在关联。

2. **文献名称**：*Structural insights into IL-17 family receptors and implications for autoimmune therapy*

**作者**：Chen, Y., et al.

**摘要**：通过IL17RE(N-term)抗体进行免疫共沉淀实验，解析了IL-17受体家族(包括IL17RE)的N端结构域与配体结合的分子机制，为靶向IL-17信号通路的药物开发提供依据。

3. **文献名称**：*IL-17RE mediates mucosal immunity to fungal infections through Th17 cell responses*

**作者**：Li, X., et al.

**摘要**：研究利用IL17RE(N-term)抗体进行免疫荧光定位，证实IL17RE在肠道上皮细胞中的高表达，并揭示其在抗真菌免疫中通过增强Th17细胞分化的调控机制。

注：以上文献为示例，实际引用需根据具体研究补充。建议通过PubMed或Google Scholar以“IL17RE antibody”或“IL17RE N-terminal function”为关键词检索最新文献。

背景信息

The IL17RE (N-term) antibody is designed to target the N-terminal region of the interleukin-17 receptor E (IL-17RE), a key component of the IL-17 receptor family. IL-17RE is a type I transmembrane protein that plays a critical role in mediating IL-17 cytokine signaling, particularly through interactions with IL-17A and IL-17F. It is known to form heterodimeric complexes with IL-17RA, another receptor subunit, to activate downstream signaling pathways such as NF-κB and MAPK, which regulate inflammatory and immune responses. The N-terminal domain of IL-17RE is essential for ligand binding and receptor activation, making it a focal point for studying IL-17-mediated biological processes.

This antibody is widely used in research to detect IL-17RE expression in various experimental models, including Western blotting, immunohistochemistry, and flow cytometry. It aids in elucidating the receptor's role in autoimmune diseases (e.g., psoriasis, rheumatoid arthritis) and infections, where dysregulated IL-17 signaling contributes to pathogenesis. By targeting the N-terminal epitope, the antibody helps differentiate IL-17RE from other receptor family members and assess post-translational modifications or truncations. Its specificity and reliability make it a valuable tool for exploring IL-17RE's tissue distribution, signaling mechanisms, and therapeutic targeting in inflammatory disorders.