| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Keratin, type II cytoskeletal 6A, Cytokeratin-6A, CK-6A, Keratin-6-alpha, mK6-alpha, Keratin-6A, K6A, Krt6a, Ker2, Krt2-6, Krt2-6a, Krt6 |
| Entrez GeneID | 16687 |
| WB Predicted band size | 59.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Krt6a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-240 amino acids from the Central region of mouse Krt6a. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mouse Krt6a(Center)抗体的3篇参考文献示例：
1. **文献名称**：*Keratin 6a Expression in Mouse Epidermal Injury Models*
**作者**：Smith A, et al.
**摘要**：研究通过免疫组化和小鼠皮肤损伤模型，使用Krt6a抗体检测其在表皮再生中的动态表达，发现Krt6a在角质形成细胞增殖中显著上调。
2. **文献名称**：*Role of Krt6a in Murine Oral Mucosa Homeostasis*
**作者**：Lee B, et al.
**摘要**：利用Krt6a特异性抗体分析口腔黏膜组织，证实Krt6a在机械应力下维持黏膜屏障完整性中的作用，并揭示其与炎症因子的关联。
3. **文献名称**：*Characterization of Krt6a-Deficient Mice Using Antibody-Based Assays*
**作者**：Chen L, et al.
**摘要**：通过Western blot和免疫荧光，比较野生型与Krt6a敲除小鼠的皮肤样本，验证抗体特异性，并发现Krt6a缺失导致表皮修复延迟。
注：上述文献为示例，实际引用需根据具体研究补充。建议通过PubMed或Google Scholar以“Krt6a antibody mouse”为关键词检索最新文献。
The Mouse Krt6a (Center) antibody is a specific immunological tool designed to detect keratin 6A (KRT6A), a member of the type II keratin family. Keratins are intermediate filament proteins critical for maintaining structural integrity in epithelial cells. KRT6A is primarily expressed in stratified epithelia, including hair follicles, nails, and oral mucosa, and is upregulated during wound healing or hyperproliferative skin conditions. This antibody targets the central region of the KRT6A protein, enabling researchers to study its expression, localization, and interactions in cellular models.
KRT6A is often co-expressed with keratin 16 (KRT16) and keratin 17 (KRT17), forming heterodimers that contribute to stress-responsive cytoskeletal networks. Mutations in KRT6A are linked to genetic disorders such as pachyonychia congenita, characterized by nail dystrophy and painful palmoplantar keratoderma. The Mouse Krt6a (Center) antibody is widely used in immunohistochemistry, immunofluorescence, and Western blotting to investigate epithelial biology, skin pathologies, and regenerative mechanisms. Its specificity for the central domain ensures reliable detection of full-length or truncated KRT6A variants, aiding research on disease mechanisms and therapeutic targets. Validation typically includes testing on knockout controls and relevant tissue samples to confirm minimal cross-reactivity with related keratins.
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