Rabbit Polyclonal KCNAB1(N-term) Antibody

The KCNAB1(N-term) antibody targets the N-terminal region of the potassium voltage-gated channel subfamily A regulatory beta subunit 1 (KCNAB1), also known as Kvβ1. This protein functions as an auxiliary subunit of voltage-gated potassium channels (Kv1 family), modulating channel gating kinetics, surface expression, and interactions with other cellular components. KCNAB1 binds to the pore-forming α-subunits, enhancing their trafficking to the plasma membrane and influencing electrical signaling in excitable tissues such as neurons and cardiac cells. The KCNAB1(N-term) antibody is commonly used in research applications like Western blotting, immunohistochemistry, and immunoprecipitation to study KCNAB1 expression, localization, and its role in regulating potassium channel activity. Its specificity for the N-terminal domain allows researchers to investigate post-translational modifications, protein-protein interactions, or functional domains critical for Kvβ1's regulatory effects. Dysregulation of KCNAB1 has been implicated in neurological disorders, cardiac arrhythmias, and epilepsy, making this antibody a valuable tool for exploring disease mechanisms. Validated in multiple species, it aids in comparative studies across experimental models, contributing to broader insights into potassium channel biology and therapeutic targeting.