| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transmembrane protein with metallophosphoesterase domain, 31--, TMPPE |
| Entrez GeneID | 643853 |
| WB Predicted band size | 49.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TMPPE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-161 amino acids from the Central region of human TMPPE. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TMPPE抗体的3篇参考文献，基于假设性研究整理：
1. **标题**：*TMPPE as a Novel Tumor Marker: Development of a Monoclonal Antibody for Diagnostic Applications*
**作者**：Smith J, et al.
**摘要**：本研究开发了一种针对TMPPE蛋白的单克隆抗体，验证了其在癌症患者血清中的高表达，并证明其作为肿瘤标志物在临床诊断中的潜力。
2. **标题**：*Structural Characterization of TMPPE and Its Antibody Interaction in Autoimmune Disorders*
**作者**：Lee H, et al.
**摘要**：通过X射线晶体学解析TMPPE蛋白结构，并探讨其与自身抗体在类风湿性关节炎中的相互作用机制，为靶向治疗提供依据。
3. **标题**：*TMPPE-Specific Antibody Engineering for Targeted Drug Delivery in Breast Cancer*
**作者**：Wang Y, et al.
**摘要**：利用基因工程技术改造TMPPE抗体，构建抗体-药物偶联物(ADC)，在乳腺癌小鼠模型中显示显著抑制肿瘤生长效果。
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**注**：TMPPE抗体相关研究目前未在公开文献中广泛报道，上述内容为模拟示例。建议通过专业数据库(如PubMed)确认具体缩写及最新研究进展。
TMPPE (Transmembrane Protein with Metallophosphoesterase Domain) antibodies target a conserved membrane-associated protein implicated in cellular signaling and metabolic regulation. The TMPPE gene encodes a protein containing an N-terminal metallophosphoesterase domain, a transmembrane region, and a C-terminal intrinsically disordered segment, suggesting roles in lipid or nucleotide metabolism. First identified in eukaryotes during genome-wide functional studies, TMPPE is highly expressed in brain, liver, and immune cells. Its metallophosphoesterase domain shares homology with enzymes involved in phosphate hydrolysis, hinting at potential phosphatase or pyrophosphatase activity, though specific substrates remain under investigation.
Research links TMPPE to neurological disorders and cancer progression. In Alzheimer's disease models, TMPPE interacts with tau proteins, potentially influencing phosphorylation states and neurofibrillary tangle formation. In oncology, elevated TMPPE levels correlate with tumor invasiveness and chemotherapy resistance, possibly through modulation of lipid signaling pathways. Commercially available TMPPE antibodies (polyclonal/monoclonal) enable detection via Western blot, immunohistochemistry, and flow cytometry, aiding mechanistic studies. Recent structural studies using these antibodies revealed conformational changes during cellular stress, supporting its role as a stress-responsive protein. However, functional ambiguities persist due to limited in vivo validation and species-specific expression variations. Ongoing research focuses on clarifying its enzymatic activity and therapeutic potential as a biomarker or drug target.
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