| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Potassium voltage-gated channel subfamily E member 2, MinK-related peptide 1, Minimum potassium ion channel-related peptide 1, Potassium channel subunit beta MiRP1, KCNE2 |
| Entrez GeneID | 9992 |
| WB Predicted band size | 14.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This KCNE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-107 amino acids from the C-terminal region of human KCNE2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于KCNE2抗体的参考文献示例(注：以下内容为模拟示例，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*KCNE2 modulates cardiac potassium channel trafficking and membrane stability*
**作者**：Abbott GW, et al.
**摘要**：本研究利用KCNE2特异性抗体，通过免疫共沉淀和免疫荧光技术，揭示了KCNE2蛋白在调节心脏钾离子通道(如hERG)的膜定位及稳定性中的关键作用，突变体KCNE2与遗传性心律失常的相关性被进一步验证。
2. **文献名称**：*Altered KCNE2 expression in hypertrophic cardiomyopathy: Insights from antibody-based proteomic analysis*
**作者**：Splawski I, et al.
**摘要**：通过Western blot和免疫组化分析，发现肥厚型心肌病患者心肌组织中KCNE2蛋白表达显著下调，提示其可能通过影响离子通道功能参与疾病病理过程，KCNE2抗体为研究提供了重要工具。
3. **文献名称**：*KCNE2 antibody validation for cross-species reactivity in cardiovascular models*
**作者**：Jones DK, et al.
**摘要**：该研究验证了KCNE2抗体在小鼠、兔及人类组织中的交叉反应性，确认其适用于多物种心脏电生理研究，并发现KCNE2与KCNQ1通道的相互作用存在物种特异性差异。
4. **文献名称**：*Role of KCNE2 in gastric acid secretion: Evidence from knockout mice and antibody-mediated inhibition*
**作者**：Roepke TK, et al.
**摘要**：利用KCNE2抗体及基因敲除模型，证明KCNE2在胃壁细胞质子泵调控中的作用，其缺失导致胃酸分泌异常，拓展了KCNE2在非心脏组织中的功能认知。
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如需具体文献，建议在PubMed或Google Scholar中检索关键词“KCNE2 antibody”、“KCNE2 potassium channel”等，并筛选近年研究。
KCNE2. a member of the KCNE family of voltage-gated potassium (Kv) channel regulatory subunits, plays a critical role in modulating cardiac and epithelial ion channel function. Encoded by the *KCNE2* gene, it primarily associates with the KCNH2 (hERG) α-subunit to form the rapid delayed rectifier potassium channel (IKr), essential for cardiac action potential repolarization. Dysfunction of KCNE2. due to mutations or abnormal expression, is linked to cardiac arrhythmias, including long QT syndrome, and has been implicated in gastric acid secretion disorders and hearing loss due to its expression in gastric parietal cells, thyroid, and inner ear tissues.
KCNE2-specific antibodies are vital tools for studying its expression, localization, and interaction with partner subunits in physiological and pathological contexts. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in research on channelopathies and tissue-specific regulatory mechanisms. Commercially available antibodies (monoclonal or polyclonal) often undergo validation in knockout models or siRNA-treated cells to confirm specificity. Understanding KCNE2's role through antibody-based assays contributes to insights into disease mechanisms and potential therapeutic targets, particularly in cardiovascular and metabolic disorders.
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