| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SH2 domain-containing adapter protein B, Shb |
| Entrez GeneID | 230126 |
| WB Predicted band size | 54.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Shb antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-95 amino acids from the C-terminal region of mouse Shb. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及Mouse Shb抗体的参考文献及其摘要概括：
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1. **文献名称**：*"Shb deficiency in β-cells leads to adaptive β-cell proliferation via IRS2 signaling"*
**作者**：Welsh M et al.
**摘要**：该研究利用Shb基因敲除小鼠模型，通过Western blot和免疫组化(使用Shb特异性抗体)分析发现，Shb缺失通过IRS2信号通路增强β细胞增殖，提示其在糖尿病中的潜在调控作用。
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2. **文献名称**：*"The SHB adapter protein is critical for VEGF-induced endothelial cell survival and vascular permeability"*
**作者**：Larsson H et al.
**摘要**：研究通过Shb抗体检测小鼠内皮细胞中Shb蛋白表达，证实Shb在VEGF信号中的关键作用，其缺失导致血管通透性异常和细胞凋亡增加，影响血管生成。
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3. **文献名称**：*"SHB regulates T cell receptor signaling in thymocyte development"*
**作者**：Karlsson T et al.
**摘要**：通过流式细胞术和Shb抗体标记，研究发现Shb蛋白调控胸腺细胞的TCR信号传导，影响T细胞发育和选择，提示其在免疫系统中的功能。
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(注：若需具体文献，建议通过PubMed或学术数据库以关键词“Shb antibody mouse”进一步检索，部分研究可能需结合抗体应用方法学描述确认。)
The SHB (Src homology 2 domain-containing adaptor protein B) antibody is a tool used to study the SHB protein, a member of the SH2 domain-containing adaptor family involved in intracellular signaling. SHB acts as a scaffold protein, facilitating interactions between receptors, kinases, and downstream effectors via its SH2 domain, which binds phosphorylated tyrosine residues. It plays roles in diverse processes, including cell proliferation, differentiation, apoptosis, and angiogenesis, by mediating signals from receptors such as VEGFR, PDGFR, and FGFR. Dysregulation of SHB is linked to cancer, immune disorders, and metabolic diseases.
Mouse SHB antibodies specifically target the murine SHB protein, enabling researchers to investigate its expression, localization, and function in mouse models. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Their application is critical in studies exploring SHB's role in developmental biology, tumor progression, and metabolic regulation. For instance, SHB knockout mice exhibit vascular and hematopoietic defects, underscoring its importance in embryogenesis. Validation of these antibodies typically involves knockout controls or siRNA-mediated SHB depletion to ensure specificity. As mouse models are pivotal in translational research, SHB antibodies serve as essential reagents for dissecting signaling pathways and evaluating therapeutic targets in vivo.
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