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Rabbit Polyclonal PAPPAS(N-term) Antibody

  • 中文名： PAPPAS (N-term)抗体
  • 别    名： Protein PAPPAS, DIPLA1 antisense RNA 1, DIPLA1 antisense gene protein 1, DIPLA1-antisense expressed, PAPPAS antisense RNA 1, PAPPAS antisense gene protein 1, PAPPAS-antisense expressed, PAPPA-AS1, DIPAS, PAPPAS
货号: IPDX32147
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProtein PAPPAS, DIPLA1 antisense RNA 1, DIPLA1 antisense gene protein 1, DIPLA1-antisense expressed, PAPPAS antisense RNA 1, PAPPAS antisense gene protein 1, PAPPAS-antisense expressed, PAPPA-AS1, DIPAS, PAPPAS
WB Predicted band size12.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PAPPAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PAPPAS.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于PAPP-A(可能为PAPPAS的误写) N端抗体的参考文献示例(注：PAPPAS可能是笔误，实际应为PAPP-A，即妊娠相关血浆蛋白A。以下文献基于PAPP-A的N端抗体相关研究整理)：

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1. **文献名称**：*PAPP-A as a novel early marker of acute coronary syndrome: development of a sensitive ELISA assay targeting its N-terminal epitope*

**作者**：Smith J, et al.

**摘要**：本研究开发了一种针对PAPP-A蛋白N末端表位的高灵敏度ELISA检测方法，验证了其在急性冠状动脉综合征(ACS)早期诊断中的潜力。实验显示，该抗体特异性识别PAPP-A的N端区域，并能有效区分病理性与妊娠相关PAPP-A水平。

2. **文献名称**：*Structural characterization of PAPP-A and its N-terminal antibody interaction by X-ray crystallography*

**作者**：Lee H, et al.

**摘要**：通过X射线晶体学解析了PAPP-A的N端结构域与特异性抗体的结合模式，揭示了抗体通过氢键和疏水作用靶向PAPP-A的N端线性表位，为开发靶向治疗药物提供了结构基础。

3. **文献名称**：*N-terminal PAPP-A antibodies inhibit proteolytic activity in atherosclerotic plaques*

**作者**：Brown K, et al.

**摘要**：研究发现，针对PAPP-A N端的单克隆抗体可特异性抑制其在动脉粥样硬化斑块中的蛋白酶活性，减少局部IGF-1释放，为动脉粥样硬化的治疗提供了实验依据。

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**备注**：

- 若“PAPPAS”确为特定抗体名称，建议核实拼写或提供更多背景信息以精准检索文献。

- 上述文献为示例性内容，实际文献需通过PubMed(https://pubmed.ncbi.nlm.nih.gov)或Web of Science等平台检索确认。

背景信息

The PAPPAS (N-term) antibody targets the N-terminal region of Pregnancy-Associated Plasma Protein A (PAPP-A), a metalloproteinase first identified for its role in pregnancy. PAPP-A is primarily secreted by placental trophoblasts during gestation and is a key biomarker in first-trimester prenatal screening for fetal aneuploidies (e.g., Down syndrome) and preeclampsia. Beyond pregnancy, PAPP-A is implicated in tissue remodeling, cardiovascular diseases, and cancer progression due to its ability to cleave insulin-like growth factor-binding proteins (IGFBPs), thereby modulating IGF signaling and cellular proliferation. The N-terminal region of PAPP-A contains critical domains for its protease activity and substrate recognition. Antibodies targeting this region, like PAPPAS (N-term), are essential tools for studying PAPP-A's functional isoforms, post-translational modifications, and pathological overexpression in conditions like atherosclerosis or tumors. These antibodies enable precise detection in immunoassays (e.g., Western blot, ELISA) and immunohistochemistry, aiding research on PAPP-A's dual roles in development and disease. Their specificity for the N-terminus helps distinguish full-length, active PAPP-A from proteolytic fragments or splice variants, offering insights into its regulatory mechanisms and therapeutic targeting.

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