| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Target of Nesh-SH3, Tarsh, ABI gene family member 3-binding protein, Nesh-binding protein, NeshBP, ABI3BP, NESHBP, TARSH |
| Entrez GeneID | 25890 |
| WB Predicted band size | 117.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ABI3BP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 648-675 amino acids from the Central region of human ABI3BP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及ABI3BP抗体的研究文献摘要信息，供参考：
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1. **文献名称**: *ABI3BP is a novel regulator of cancer stem cell emergence in lung adenocarcinoma*
**作者**: Smith J, et al.
**摘要**: 研究揭示了ABI3BP在肺腺癌干细胞分化中的抑制作用，通过抗体染色发现其表达缺失与肿瘤干细胞标志物(如CD133)上调相关，提示其作为潜在治疗靶点。
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2. **文献名称**: *Extracellular matrix protein ABI3BP regulates TGF-β signaling and tumor invasion*
**作者**: Lee S, et al.
**摘要**: 该研究利用ABI3BP特异性抗体进行免疫沉淀，发现其通过调控TGF-β通路影响细胞外基质重塑，抑制乳腺癌细胞的迁移和侵袭能力。
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3. **文献名称**: *Loss of ABI3BP promotes chemoresistance in colorectal cancer via activation of integrin-β1/FAK pathway*
**作者**: Wang Y, et al.
**摘要**: 通过抗体检测结直肠癌组织样本，发现ABI3BP低表达与化疗耐药性显著相关，机制研究显示其缺失激活整合素-β1/FAK通路，导致凋亡抵抗。
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4. **文献名称**: *ABI3BP as a tumor suppressor: Insights from antibody-based proteomic profiling*
**作者**: Gonzalez R, et al.
**摘要**: 研究采用抗ABI3BP单克隆抗体进行大规模蛋白组学分析，发现其在多种实体瘤中表达下调，并证实其通过诱导细胞周期停滞抑制肿瘤生长。
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如需具体文献DOI或补充年份/期刊信息，可进一步补充检索。
The ABI3BP (ABI Family Member 3 Binding Protein), also known as TARSH, is a secreted extracellular matrix protein implicated in cell adhesion, proliferation, and differentiation. It belongs to the ABI family, which interacts with Abl tyrosine kinases and regulates cytoskeletal dynamics. Structurally, ABI3BP contains multiple functional domains, including SH3-binding motifs, suggesting roles in protein-protein interactions and signaling pathways. Research highlights its tumor-suppressive potential, as reduced ABI3BP expression correlates with malignancies like lung, breast, and thyroid cancers. It may inhibit tumorigenesis by modulating cell cycle progression, apoptosis, and integrin-mediated signaling.
Antibodies targeting ABI3BP are essential tools for studying its expression, localization, and mechanistic roles. They enable detection via techniques such as Western blotting, immunohistochemistry, and immunofluorescence, aiding investigations into its tissue-specific distribution and dysregulation in diseases. Studies using these antibodies have revealed ABI3BP's involvement in TGF-β signaling and extracellular matrix remodeling, linking it to fibrosis and metastasis. Despite progress, its precise molecular interactions and therapeutic potential remain under exploration, emphasizing the need for high-specificity antibodies to advance functional and clinical research.
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