| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Non-secretory ribonuclease, Eosinophil-derived neurotoxin, RNase UpI-2, Ribonuclease 2, RNase 2, Ribonuclease US, RNASE2, EDN, RNS2 |
| Entrez GeneID | 6036 |
| WB Predicted band size | 18.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This RNASE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-152 amino acids from the C-terminal region of human RNASE2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4条关于 **RNASE2抗体** 的参考文献及其简要摘要：
1. **"Monoclonal antibodies against human RNASE2/ECP: Characterization and clinical utility"**
*Authors: Byström J, et al.*
**摘要**: 研究开发了针对人RNASE2(嗜酸性粒细胞阳离子蛋白，ECP)的单克隆抗体，验证了其在ELISA和免疫组化中的特异性，并探讨其在过敏性疾病和寄生虫感染患者血清ECP检测中的应用。
2. **"RNASE2 as a biomarker in asthma: Role of polyclonal antibodies in sputum analysis"**
*Authors: Tai PC, et al.*
**摘要**: 通过多克隆抗体检测痰液和血液中RNASE2的水平，发现其与哮喘严重程度和嗜酸性粒细胞炎症相关，支持其作为气道炎症的生物标志物。
3. **"Structural mapping of RNASE2 epitopes using phage display-derived antibodies"**
*Authors: Zhang L, et al.*
**摘要**: 利用噬菌体展示技术筛选靶向RNASE2特定表位的抗体，结合X射线晶体学解析抗体-抗原结合模式，为开发治疗性抗体提供结构基础。
4. **"Autoantibodies to RNASE2 in autoimmune diseases: Diagnostic implications"**
*Authors: Lee JJ, et al.*
**摘要**: 报道在系统性红斑狼疮(SLE)和类风湿关节炎(RA)患者血清中发现抗RNASE2自身抗体，提示其可能参与自身免疫病理机制，并具有潜在诊断价值。
(注：以上文献信息为示例性内容，实际引用需以具体论文数据为准。)
The RNASE2 antibody is a crucial tool for studying ribonuclease 2 (RNASE2), a protein encoded by the RNASE2 gene, also known as eosinophil-derived neurotoxin (EDN) or eosinophil cationic protein (ECP). RNASE2 belongs to the ribonuclease A superfamily and is predominantly expressed in eosinophils, immune cells involved in allergic responses and parasitic defense. This enzyme exhibits ribonucleolytic activity, contributing to host defense by degrading viral RNA and modulating immune responses. It also plays roles in inflammation, tissue remodeling, and cytotoxic processes, with elevated levels observed in conditions like asthma, allergies, and eosinophilic disorders.
RNASE2 antibodies are designed to specifically detect and quantify RNASE2 in various biological samples, including tissues, blood, or cultured cells. These antibodies (polyclonal or monoclonal) are typically generated by immunizing animals with recombinant RNASE2 protein or peptide fragments. They enable researchers to investigate RNASE2's expression patterns, localization, and functional roles through techniques like immunohistochemistry (IHC), Western blotting, ELISA, or immunofluorescence. Validated antibodies show high specificity, often confirmed via knockout cell lines or competitive assays.
In clinical research, RNASE2 antibodies aid in exploring its potential as a biomarker for eosinophil activation in diseases such as asthma, chronic rhinosinusitis, or inflammatory bowel disease. They also support drug development targeting eosinophil-mediated pathologies. Proper validation and optimization are critical to ensure reliability across experimental models.
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