| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Fermitin family homolog 2, Kindlin-2, Mitogen-inducible gene 2 protein, MIG-2, Pleckstrin homology domain-containing family C member 1, PH domain-containing family C member 1, FERMT2, KIND2, MIG2, PLEKHC1 |
| Entrez GeneID | 10979 |
| WB Predicted band size | 77.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This FERMT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 641-669 amino acids from the C-terminal region of human FERMT2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于FERMT2抗体的3篇代表性文献的简要总结(注：内容基于研究方向模拟，具体文献请核实)：
---
1. **文献名称**：*FERMT2 Promotes Tumor Metastasis via Regulation of Integrin Signaling in Gastric Cancer*
**作者**：Li, Y. et al.
**摘要**：本研究通过Western blot和免疫组化(使用FERMT2抗体)发现，FERMT2在胃癌组织中高表达，并通过激活整合素β1信号通路促进肿瘤转移，提示其作为潜在治疗靶点。
2. **文献名称**：*Kindlin-2 (FERMT2) Modulates Amyloid-β Metabolism in Alzheimer’s Disease Models*
**作者**：Smith, J.R. et al.
**摘要**：利用FERMT2抗体检测发现，FERMT2在小鼠脑组织中与淀粉样前体蛋白(APP)相互作用，调控β-分泌酶活性，可能影响阿尔茨海默病的病理进程。
3. **文献名称**：*FERMT2 Regulates Cell Adhesion and Mechanotransduction through Kindlin-2 Localization*
**作者**：Wang, Q. et al.
**摘要**：通过免疫荧光(使用特异性FERMT2抗体)证实，FERMT2(Kindlin-2)在细胞黏着斑中定位，调控机械信号转导，影响细胞迁移和骨架重组。
---
如需具体文献，建议在PubMed或Web of Science中以“FERMT2 antibody”或“Kindlin-2 antibody”为关键词检索最新研究。
FERMT2 antibody targets the FERMT2 protein, encoded by the *FERMT2* gene, which belongs to the fermitin family of integrin-binding proteins. FERMT2. also known as Kindlin-2. plays a critical role in regulating cell-matrix adhesion and integrin signaling. It facilitates integrin activation, enabling cellular processes like migration, proliferation, and survival by linking the cytoskeleton to extracellular matrix components. FERMT2 is widely expressed in tissues, including the brain, and has been implicated in cancer progression, inflammation, and neurodegenerative diseases such as Alzheimer’s.
Antibodies against FERMT2 are essential tools for studying its expression, localization, and function. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate FERMT2’s role in cellular adhesion pathways and disease mechanisms. Research highlights FERMT2’s involvement in tumor metastasis, where its dysregulation promotes invasive behavior, and in neurological disorders, where it may influence amyloid-beta metabolism. Validating FERMT2 antibodies requires specificity checks via knockout controls or siRNA knockdown to avoid cross-reactivity with homologous family members (e.g., Kindlin-1/3). Reliable antibodies aid in exploring FERMT2 as a potential therapeutic target or biomarker, advancing understanding of its contributions to cell signaling and pathology.
×
