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Rabbit Polyclonal MLC1 Antibody

  • 中文名: MLC1抗体
  • 别    名: Membrane protein MLC1, MLC1, KIAA0027, WKL1
货号: IPDX32137
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMembrane protein MLC1, MLC1, KIAA0027, WKL1
Entrez GeneID23209
WB Predicted band size41.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis MLC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 337-366 amino acids from the C-terminal region of human MLC1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3-4条关于MLC1抗体的假设参考文献示例,供参考:

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1. **文献名称**:*"MLC1 Antibody Characterization in Megalencephalic Leukoencephalopathy Diagnosis"*

**作者**:Van der Knaap, M.S. et al.

**摘要**:本研究开发了一种特异性抗MLC1抗体,用于检测患者脑组织或血细胞中MLC1蛋白的异常表达,证实其在遗传性脑白质病(MLC)中的诊断价值,并揭示了蛋白定位缺陷与基因突变的关联。

2. **文献名称**:*"Role of MLC1 in Astrocyte Volume Regulation: Insights from Antibody-Based Imaging"*

**作者**:Ridder, M.C. et al.

**摘要**:通过免疫荧光和Western blot技术,利用MLC1抗体揭示其在星形胶质细胞中的表达模式,证明MLC1参与细胞容积调节,突变导致渗透压敏感性异常,可能与脑水肿病理机制相关。

3. **文献名称**:*"A Novel Monoclonal Antibody for MLC1 Quantification in Cerebrospinal Fluid"*

**作者**:Sánchez-Olea, R. et al.

**摘要**:报道一种新型单克隆抗体的制备,可高灵敏度检测脑脊液中MLC1水平,为MLC疾病的非侵入性诊断及疗效监测提供潜在生物标志物。

4. **文献名称**:*"MLC1 Interaction with Tight Junction Proteins Revealed by Co-Immunoprecipitation"*

**作者**:Dubey, M. et al.

**摘要**:利用MLC1抗体进行免疫共沉淀实验,发现其与紧密连接蛋白(如Claudin-1)的相互作用,提示MLC1在血脑屏障功能中的潜在作用及突变导致神经退化的分子机制。

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**注**:以上文献为示例性质,若需真实文献,建议通过PubMed或Google Scholar检索关键词“MLC1 antibody”或“MLC1 protein function”获取最新研究。

背景信息

The MLC1 antibody is a crucial tool in studying megalencephalic leukoencephalopathy with subcortical cysts (MLC), a rare autosomal recessive leukodystrophy caused by mutations in the *MLC1* gene. MLC1 is a membrane protein predominantly expressed in astrocytes, where it plays a role in ion homeostasis, cell volume regulation, and astrocyte-axon interactions. Mutations in *MLC1* disrupt these functions, leading to macrocephaly, progressive white matter degeneration, and fluid-filled cysts in the brain. The MLC1 antibody is used to detect and localize the MLC1 protein in experimental models (e.g., brain tissue, cultured astrocytes) via techniques like immunohistochemistry, Western blotting, or immunofluorescence. Its applications include elucidating MLC1's physiological role, studying disease mechanisms in MLC, and validating cellular or animal models of the disorder. Research using this antibody has highlighted MLC1's interaction with other proteins (e.g., GlialCAM) and its potential involvement in ion channel complexes. Despite advances, the exact molecular function of MLC1 remains under investigation, and the antibody remains vital for both basic research and diagnostic confirmation of MLC-related pathologies.

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