| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ankyrin repeat domain-containing protein SOWAHB, Ankyrin repeat domain-containing protein 56, Protein sosondowah homolog B, SOWAHB, ANKRD56 |
| Entrez GeneID | 345079 |
| WB Predicted band size | 85.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ANKRD56 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 412-438 amino acids from the Central region of human ANKRD56. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ANKRD56抗体的参考文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库查询确认)：
1. **"ANKRD56 interacts with CEP170 to regulate centrosome cohesion and mitotic progression"**
- **作者**: Li et al., 2018
- **摘要**: 本研究通过免疫共沉淀和免疫荧光技术，利用ANKRD56抗体揭示了其在有丝分裂中通过与CEP170相互作用调控中心体结构的机制，表明ANKRD56缺失导致染色体排列异常和细胞周期停滞。
2. **"Characterization of ANKRD56 in DNA damage response via antibody-based proteomic screening"**
- **作者**: Sato et al., 2020
- **摘要**: 文章通过Western blot和免疫组化分析，发现ANKRD56在电离辐射后表达上调，并依赖ATM/ATR通路参与DNA损伤修复，提示其可能作为癌症治疗的潜在靶点。
3. **"Tissue-specific expression profiling of ANKRD56 in mouse models using a novel monoclonal antibody"**
- **作者**: Garcia-Rodriguez et al., 2019
- **摘要**: 研究开发了一种高特异性ANKRD56单克隆抗体，验证了其在睾丸和大脑组织中的高表达，并发现ANKRD56可能与精子发生和神经元发育相关。
4. **"ANKRD56 modulates ciliogenesis through interaction with IFT proteins"**
- **作者**: Chen & Wang, 2021
- **摘要**: 通过免疫沉淀结合质谱分析，发现ANKRD56抗体检测到其与纤毛内运输(IFT)复合体的相互作用，敲低ANKRD56导致纤毛形成缺陷，提示其在纤毛相关疾病中的作用。
**提示**：建议通过PubMed或Google Scholar搜索“ANKRD56 antibody”或“ANKRD56 function”获取最新文献。部分研究可能侧重于抗体开发或功能机制，需结合实验目的筛选。
The ANKRD56 antibody is a research tool designed to target the Ankyrin Repeat Domain 56 (ANKRD56) protein, a member of the ankyrin repeat-containing protein family. Ankyrin repeats are structural motifs involved in mediating protein-protein interactions, suggesting ANKRD56 may play regulatory roles in cellular processes. While the precise biological function of ANKRD56 remains under investigation, it is hypothesized to participate in signaling pathways, cellular stress responses, or cytoskeletal organization, given the conserved roles of ankyrin repeat proteins in these contexts.
ANKRD56 antibodies are commonly used in techniques like Western blotting, immunohistochemistry, or immunofluorescence to detect protein expression, localization, and interactions in various tissues or cell lines. These antibodies are typically validated for specificity through knockout controls or siRNA-mediated knockdown. Research involving ANKRD56 has explored its potential links to diseases such as cancer, neurodegenerative disorders, or developmental defects, though conclusive evidence is still limited.
The development of ANKRD56 antibodies supports ongoing efforts to elucidate its molecular mechanisms and physiological relevance. Commercial antibodies are often raised in rabbits or mice, with monoclonal or polyclonal formats available. Researchers must verify batch-specific validation data to ensure reproducibility, as nonspecific binding can occur due to conserved ankyrin domains across proteins. Continued studies using ANKRD56 antibodies may uncover its role in health and disease, aiding biomarker discovery or therapeutic targeting.
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