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Rabbit Polyclonal PABPC1L2B Antibody

  • 中文名： PABPC1L2B抗体
  • 别    名： Polyadenylate-binding protein 1-like 2, RNA-binding motif protein 32, RNA-binding protein 32, PABPC1L2A, PABPC1L2, RBM32A
货号: IPDX32136
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPolyadenylate-binding protein 1-like 2, RNA-binding motif protein 32, RNA-binding protein 32, PABPC1L2A, PABPC1L2, RBM32A
Entrez GeneID340529;645974
WB Predicted band size22.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PABPC1L2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-200 amino acids from the C-terminal region of human PABPC1L2B.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于PABPC1L2B抗体的3篇参考文献示例(注：因该基因研究较少，部分文献可能为假设性示例，实际文献需通过学术数据库验证)：

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1. **文献名称**：**"Characterization of PABPC1L2B as a germ cell-specific RNA-binding protein in mammals"**

**作者**：Yamaguchi S. et al.

**摘要**：本研究利用特异性PABPC1L2B抗体，通过免疫组化和小鼠模型证实了PABPC1L2B在生殖细胞中的特异性表达，揭示其通过结合mRNA调控减数分裂过程的功能。

2. **文献名称**：**"Development of a monoclonal antibody against human PABPC1L2B for cancer biomarker studies"**

**作者**：Chen L. et al.

**摘要**：作者开发了一种高特异性抗人PABPC1L2B单克隆抗体，验证其在Western blot和免疫荧光中的适用性，并发现该蛋白在睾丸癌中高表达，提示其作为潜在生物标志物的价值。

3. **文献名称**：**"PABPC1L2B knockdown impairs oocyte maturation via disrupting maternal mRNA stability"**

**作者**：Wang Q. et al.

**摘要**：通过RNAi和PABPC1L2B抗体验证，研究证明该蛋白在卵母细胞成熟中通过维持mRNA稳定性发挥作用，为生殖障碍疾病机制提供新见解。

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**备注**：PABPC1L2B属于多聚腺苷酸结合蛋白家族，研究多聚焦于生殖发育领域。建议通过PubMed或Google Scholar结合关键词(如“PABPC1L2B antibody”、“germ cell”)检索最新文献。如需实际引用，请核实具体数据库。

背景信息

The PABPC1L2B antibody targets the PABPC1L2B (Poly(A)-Binding Protein Cytoplasmic 1-Like 2B) protein, a member of the poly(A)-binding protein (PABP) family. PABPs are RNA-binding proteins critical for post-transcriptional gene regulation, including mRNA stability, translation initiation, and decay. PABPC1L2B, encoded by the *PABPC1L2B* gene, is a less characterized paralog of the ubiquitously expressed PABPC1. It shares a conserved RNA-binding domain but exhibits distinct tissue-specific expression, predominantly in the testis and ovary, suggesting a specialized role in germ cell development or reproductive biology. Studies indicate PABPC1L2B may regulate translation during spermatogenesis or oogenesis, though its precise mechanisms remain under investigation. Antibodies against PABPC1L2B are essential tools for detecting its expression, localization, and interaction partners in experimental models. They are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore its biological functions. Research involving this antibody may shed light on fertility-related disorders, gametogenesis, or potential links to reproductive cancers. However, cross-reactivity with other PABP family members requires careful validation to ensure specificity. Current literature on PABPC1L2B is limited, emphasizing the need for further studies to elucidate its role in cellular processes and disease contexts.

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