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Rabbit Polyclonal ATAD3C Antibody

  • 中文名: ATAD3C抗体
  • 别    名: ATPase family AAA domain-containing protein 3C, ATAD3C
货号: IPDX32134
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesATPase family AAA domain-containing protein 3C, ATAD3C
Entrez GeneID219293
WB Predicted band size46.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis ATAD3C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-172 amino acids from the Central region of human ATAD3C.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于ATAD3C抗体的3篇示例文献摘要(注:以下内容为模拟示例,非真实文献):

1. **文献名称**:*ATAD3C promotes tumor progression in triple-negative breast cancer via mitochondrial metabolism regulation*

**作者**:He, Y. et al. (2021)

**摘要**:本研究利用特异性ATAD3C抗体,通过Western blot和免疫组化技术,发现ATAD3C在三阴性乳腺癌中显著高表达,并通过调控线粒体氧化磷酸化促进肿瘤生长和转移。

2. **文献名称**:*Development of a monoclonal antibody against human ATAD3C for functional studies*

**作者**:Smith, J. et al. (2020)

**摘要**:该文献报道了一种新型ATAD3C单克隆抗体的开发与验证,证实其可特异性识别ATAD3C蛋白(与ATAD3A/B无交叉反应),并成功应用于流式细胞术和免疫荧光实验,揭示了ATAD3C在线粒体内膜中的定位。

3. **文献名称**:*ATAD3C as a potential biomarker in prostate cancer: antibody-based detection and clinical correlation*

**作者**:Lee, S. et al. (2019)

**摘要**:研究利用ATAD3C抗体对前列腺癌组织进行检测,发现ATAD3C表达与Gleason评分和耐药性呈正相关,提示其作为预后标志物的潜力。

4. **文献名称**:*ATAD3C interacts with MYC oncoprotein to drive hepatocellular carcinoma*

**作者**:Wang, L. et al. (2022)

**摘要**:通过免疫共沉淀(使用ATAD3C抗体)和基因敲除实验,揭示了ATAD3C与MYC蛋白的相互作用机制,及其在肝癌细胞代谢重编程中的关键作用。

(注:实际文献需通过PubMed、Google Scholar等平台以“ATAD3C antibody”为关键词检索核实。)

背景信息

The ATAD3C antibody targets a member of the AAA+ ATPase family, specifically the ATAD3 (ATPase family AAA domain-containing protein 3) subfamily, which includes ATAD3A, ATAD3B, and ATAD3C. These proteins localize to the mitochondrial inner membrane and play roles in mitochondrial dynamics, cholesterol metabolism, and mtDNA regulation. ATAD3C, a less-studied isoform, shares structural homology with ATAD3A but exhibits distinct expression patterns, with higher levels observed in certain cancers and reproductive tissues. Research suggests ATAD3C may contribute to cancer progression by influencing mitochondrial function, apoptosis resistance, and cellular proliferation. Its overexpression has been linked to poor prognosis in malignancies like ovarian and prostate cancer. The ATAD3C antibody is primarily used in research to investigate its tissue-specific expression, subcellular localization, and interactions with mitochondrial proteins. It aids in elucidating ATAD3C's role in diseases through techniques like Western blotting, immunofluorescence, and immunohistochemistry. Recent studies also explore its potential as a biomarker or therapeutic target. However, challenges remain in distinguishing ATAD3C-specific functions from other ATAD3 isoforms due to high sequence similarity, necessitating antibody validation for isoform specificity. Commercial ATAD3C antibodies are typically polyclonal, raised against unique peptide regions to ensure selectivity.

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