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Rabbit Polyclonal RHPN1 Antibody

  • 中文名： RHPN1抗体
  • 别    名： Rhophilin-1, GTP-Rho-binding protein 1, RHPN1, KIAA1929
货号: IPDX31946
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesHS1; GW128; YWHAA; KCIP-1; HEL-S-1
Entrez GeneID7529
clone3D2E10
WB Predicted band size28kDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human YWHAB (AA: 1-246) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是3篇关于RHPN1抗体的虚拟参考文献示例(基于研究领域常见方向，非真实文献)：

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1. **文献名称**：RHPN1 as a Prognostic Biomarker in Colorectal Cancer: Antibody-Based Detection and Clinical Significance

**作者**：Zhang L, et al.

**摘要**：研究通过免疫组化(使用抗RHPN1抗体)分析结直肠癌组织中RHPN1蛋白表达水平，发现其高表达与患者不良预后及转移风险增加显著相关，提示RHPN1可能作为潜在治疗靶点。

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2. **文献名称**：Development of a Monoclonal Antibody Targeting RHPN1 for Functional Studies in Cytoskeletal Remodeling

**作者**：Wang Y, et al.

**摘要**：报道了一种新型抗RHPN1单克隆抗体的开发，验证其特异性后，应用于细胞免疫荧光实验，证明RHPN1通过调控RhoA/ROCK通路影响细胞骨架重组和迁移能力。

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3. **文献名称**：RHPN1 Antibody-Based Screening Reveals Its Role in Pancreatic Cancer Cell Invasion

**作者**：Kim S, et al.

**摘要**：利用RHPN1抗体进行Western blot和流式细胞术分析，发现敲低RHPN1显著抑制胰腺癌细胞侵袭，机制可能与整合素信号通路异常激活有关。

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注：以上内容为模拟文献，实际研究中建议通过PubMed或Web of Science以“RHPN1 antibody”或“RHPN1 biomarker”等关键词检索最新论文。

背景信息

The RHPN1 (RhoGAP interacting with CIP4 homologs 1) antibody is a tool used to study the RHPN1 protein, which plays a role in Rho GTPase signaling pathways regulating cytoskeletal dynamics, cell adhesion, and membrane trafficking. RHPN1 contains a Rho-binding domain and interacts with proteins like CIP4. linking RhoA activity to cellular processes such as vesicle transport and actin reorganization. It is implicated in diseases, including cancer, where its overexpression correlates with tumor progression, metastasis, and poor prognosis in breast, ovarian, and colorectal cancers. RHPN1 antibodies are crucial for detecting protein expression levels, localization, and interactions in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Polyclonal antibodies target multiple epitopes for sensitivity, while monoclonal antibodies offer specificity. Researchers use these antibodies to explore RHPN1's role in pathological mechanisms, such as promoting epithelial-mesenchymal transition (EMT) or modulating drug resistance. Validation via knockout cells or siRNA is essential to confirm antibody specificity, as cross-reactivity with paralogs (e.g., RHPN2) may occur. Studies also investigate RHPN1 as a potential therapeutic target, particularly in Rho-driven cancers. Its association with rare genetic disorders, like developmental syndromes, further underscores its biological relevance. Commercial RHPN1 antibodies are available from multiple suppliers, often accompanied by validation data in specific applications.

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