| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Peptidyl-prolyl cis-trans isomerase-like 2, PPIase, PPIL2 (HGNC:9261) |
| Entrez GeneID | 23759 |
| WB Predicted band size | 58.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PPIL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 402-431 amino acids from the C-terminal region of human PPIL2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PPIL2抗体的3篇参考文献示例，包含文献名称、作者及摘要概括：
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### 1. **"PPIL2 regulates alternative splicing and immune response in T cells"**
**作者**: Zhang Y, et al.
**摘要**: 本研究通过Western blot和免疫共沉淀技术，利用PPIL2特异性抗体揭示了PPIL2在T细胞中对RNA剪接的调控作用。研究发现PPIL2通过结合剪接因子影响免疫相关基因的可变剪接，为自身免疫疾病的机制提供了新见解。
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### 2. **"Prognostic value of PPIL2 overexpression in hepatocellular carcinoma"**
**作者**: Li H, et al.
**摘要**: 文章通过免疫组化(使用商业化PPIL2抗体)分析肝癌组织中PPIL2的表达水平，发现其高表达与患者不良预后显著相关。实验进一步表明PPIL2可能通过调控细胞周期蛋白促进肿瘤进展。
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### 3. **"PPIL2 interacts with HSP90 to modulate protein folding in cancer cells"**
**作者**: Wang X, et al.
**摘要**: 本研究利用PPIL2抗体进行免疫沉淀和质谱分析，发现PPIL2与HSP90形成复合物，参与癌症细胞内错误折叠蛋白的修复过程。抑制PPIL2可增强化疗药物对癌细胞的杀伤效果。
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**备注**：PPIL2抗体相关研究相对较少，上述文献为示例性质。实际检索时建议结合具体数据库(如PubMed、Web of Science)并验证最新进展。若需具体文献链接或补充信息，可进一步说明。
PPIL2 (Peptidylprolyl Isomerase Like 2) is a member of the cyclophilin family of proteins, which are characterized by their peptidyl-prolyl cis-trans isomerase (PPIase) activity. This enzyme activity facilitates protein folding and conformational changes by catalyzing the isomerization of peptide bonds involving proline residues. PPIL2 is encoded by the PPIL2 gene located on human chromosome 22q13.2 and shares structural homology with other cyclophilins, though its specific functional roles remain less defined compared to well-studied members like cyclophilin A (CypA).
PPIL2 is implicated in diverse cellular processes, including transcriptional regulation, RNA splicing, and immune response modulation. It interacts with components of the spliceosome complex, suggesting a role in mRNA processing. Studies also link PPIL2 to T-cell activation and viral replication, particularly in HIV-1. where it may influence viral integration through interactions with host factors. Antibodies targeting PPIL2 are essential tools for investigating its expression, localization, and molecular interactions. They are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to study its involvement in diseases like cancer, where altered PPIL2 expression has been observed in hepatocellular carcinoma and gliomas. Additionally, PPIL2 antibodies aid in exploring its potential as a biomarker or therapeutic target, given its regulatory roles in pathways associated with cell proliferation and immune evasion. Research continues to elucidate its precise mechanisms in health and disease.
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