关键信息
-
基因名
MAP1A
- 应用
-
别名
MAP1A；MAP1L；Microtubule-associated Protein 1A
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P78559
-
表达区间
2567-2803aa
-
氨基酸序列
DPRPSPPRPDVCMADPEGLSSESGRVERLREKEKVQGRVGRRAPGKAKPASPARRLDLRGKRSPTPGKGPADRASRAPPRPRSTTSQVTPAEEKDGHSPMSKGLVNGLKAGPMALSSKGSSGAPVYVDLAYIPNHCSGKTADLDFFRRVRASYYVVSGNDPANGEPSRAVLDALLEGKAQWGENLQVTLIPTHDTEVTREWYQQTHEQQQQLNVLVLASSSTVVMQDESFPACKIEF
-
分子量
30.0 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
MAP1A, or Microtubule-Associated Protein 1A, is a crucial protein involved in the regulation of microtubule dynamics and cellular structure. It plays a significant role in neuronal development, supporting the stability of microtubules and facilitating intracellular transport. Recent studies have highlighted MAP1A's involvement in neurodegenerative diseases, including Alzheimer's and tauopathies, where abnormal tau protein aggregation disrupts microtubule function. Understanding MAP1A's structure and dynamics through recombinant protein studies is essential for elucidating its role in neuronal health and disease. Researchers focus on developing recombinant forms of MAP1A to analyze its interactions with microtubules and other cellular proteins. This approach allows for a detailed examination of its binding properties, conformational changes, and the impact of post-translational modifications. Consequently, studying MAP1A recombinant proteins can illuminate potential therapeutic targets for neurodegenerative disorders, offering insight into how modulation of this protein could help restore normal microtubule function and improve neuronal resilience. The ongoing investigation into MAP1A's mechanisms highlights its importance in cell biology, particularly in understanding the complex interactions that govern neuronal stability and function.
