| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GPI transamidase component PIG-S, Phosphatidylinositol-glycan biosynthesis class S protein, PIGS |
| Entrez GeneID | 94005 |
| WB Predicted band size | 61.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PIGS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-555 amino acids from the C-terminal region of human PIGS. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PIGS抗体的模拟参考文献示例(非真实文献，仅供格式参考)：
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1. **文献名称**：*Autoantibodies targeting PIGS in autoimmune encephalitis: Clinical and molecular characterization*
**作者**：Smith A, et al.
**摘要**：该研究报道了在自身免疫性脑炎患者中发现针对PIGS蛋白的自身抗体，揭示了其与神经系统症状的相关性，并通过细胞模型证实抗体干扰GPI锚定蛋白功能，导致神经元信号传导异常。
2. **文献名称**：*PIGS gene mutations and anti-PIGS antibodies in inherited glycosylphosphatidylinositol deficiency disorders*
**作者**：Tanaka K, et al.
**摘要**：研究分析了PIGS基因突变患者的临床表型，发现部分患者体内存在抗PIGS蛋白的抗体，可能加剧GPI锚定蛋白缺陷相关的血液系统异常和发育迟缓。
3. **文献名称**：*Development of a high-specificity monoclonal antibody against human PIGS for diagnostic applications*
**作者**：Chen L, et al.
**摘要**：团队成功开发了针对人源PIGS蛋白的单克隆抗体，验证了其在流式细胞术和免疫组化中的应用，为GPI锚定相关疾病的诊断提供了新工具。
4. **文献名称**：*Anti-PIGS antibody-mediated complement activation in paroxysmal nocturnal hemoglobinuria*
**作者**：Wang Y, et al.
**摘要**：探讨了阵发性夜间血红蛋白尿(PNH)患者中抗PIGS抗体与补体异常激活的关联，提出抗体可能通过破坏GPI合成通路参与溶血机制。
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**说明**：以上文献为模拟示例，实际研究需通过PubMed、Google Scholar等平台检索关键词(如“PIGS antibody”“anti-PIGS autoantibody”“GPI biosynthesis”)获取真实文献。PIGS相关研究多聚焦于其基因突变导致的GPI合成缺陷及继发病理机制，抗体研究相对较少。
PIGS antibodies are associated with research on glycosylphosphatidylinositol (GPI)-anchored proteins, which play critical roles in cell signaling, adhesion, and immune regulation. The PIGS gene encodes a key enzyme in the GPI biosynthesis pathway, essential for attaching GPI anchors to target proteins. Defects in GPI anchor synthesis, including PIGS mutations, are linked to rare genetic disorders like inherited GPI deficiency (IGD), characterized by neurodevelopmental delays, seizures, and dysmorphic features.
Interest in PIGS antibodies stems from their utility in studying GPI-anchored protein expression and related pathologies. For example, disrupted GPI anchoring is implicated in paroxysmal nocturnal hemoglobinuria (PNH), where somatic mutations in PIGA (a related gene) lead to deficient surface proteins like CD55/CD59. While PIGS itself is less commonly mutated in PNH, antibodies targeting GPI-anchored proteins or biosynthesis components aid in diagnosing and monitoring such conditions. Additionally, PIGS antibodies are used in basic research to explore GPI biosynthesis mechanisms, cellular trafficking, and their roles in diseases like cancer, where altered GPI-protein expression may influence metastasis or immune evasion. These tools contribute to therapeutic development, including antibody-based therapies targeting GPI-linked biomarkers.
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