| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cytochrome c oxidase assembly factor 4 homolog, mitochondrial, Coiled-coil-helix-coiled-coil-helix domain-containing protein 8, E2-induced gene 2 protein, COA4, CHCHD8, E2IG2 |
| Entrez GeneID | 51287 |
| WB Predicted band size | 10.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CHCH8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-84 amino acids from the C-terminal region of human CHCH8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CHCHD8抗体的参考文献示例(注：以下内容为假设性示例，实际文献需通过学术数据库验证)：
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1. **文献名称**：*CHCHD8 regulates mitochondrial dynamics and apoptosis in cancer cells*
**作者**：Smith A, et al.
**摘要**：本研究利用特异性CHCHD8抗体，通过免疫印迹和免疫荧光技术，揭示了CHCHD8在线粒体融合-分裂平衡中的作用。结果表明，CHCHD8缺失导致线粒体碎片化并增强癌细胞对凋亡的敏感性。
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2. **文献名称**：*A novel antibody-based detection of CHCHD8 in neurodegenerative disorders*
**作者**：Zhang L, et al.
**摘要**：作者开发了一种高特异性CHCHD8单克隆抗体，并应用于阿尔茨海默病模型小鼠的脑组织分析。研究发现CHCHD8表达水平与神经元线粒体功能障碍显著相关。
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3. **文献名称**：*CHCHD8 interaction with HIF-1α promotes tumor progression under hypoxia*
**作者**：Wang Y, et al.
**摘要**：通过CHCHD8抗体的免疫共沉淀实验，研究发现CHCHD8与HIF-1α在低氧肿瘤微环境中存在直接相互作用，促进血管生成和肿瘤转移。
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4. **文献名称**：*Validation of a commercial CHCHD8 antibody for immunohistochemical applications*
**作者**：Johnson R, et al.
**摘要**：本文系统评估了某商业CHCHD8抗体的特异性，验证其在人组织切片中的适用性，为临床病理学中CHCHD8蛋白表达分析提供了标准化方案。
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**建议**：
- 实际文献可通过**PubMed**或**Google Scholar**以关键词“CHCHD8 antibody”、“CHCHD8 function”检索。
- 部分研究可能侧重CHCHD8在代谢、癌症或神经疾病中的作用，抗体应用多涉及Western blot、IHC或IP实验。
- 推荐查阅近年文献(如2020年后)，以获取最新进展。
The CHCHD8 antibody is a research tool designed to target the CHCHD8 (coiled-coil-helix-coiled-coil-helix domain-containing protein 8) protein, a mitochondrial protein implicated in cellular energy metabolism, apoptosis regulation, and oxidative stress response. CHCHD8 belongs to the CHCHD protein family, which is characterized by twin CX9C motifs and plays roles in maintaining mitochondrial cristae structure and function. Studies suggest its involvement in mitochondrial dynamics, including fusion-fission balance, and interactions with the mitochondrial contact site and cristae organizing system (MICOS).
Dysregulation of CHCHD8 has been linked to neurodegenerative diseases (e.g., Alzheimer's and Parkinson’s) and cancers due to its role in metabolic reprogramming and stress adaptation. The CHCHD8 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression levels, subcellular localization, and interactions in disease models. Recent research also explores its potential as a biomarker for mitochondrial dysfunction. Commercial CHCHD8 antibodies are typically raised in rabbits or mice, with validation data confirming specificity through knockdown/knockout controls. Ongoing studies aim to clarify its mechanistic contributions to pathologies and therapeutic targeting opportunities.
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