| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | U2 snRNP-associated SURP motif-containing protein, 140 kDa Ser/Arg-rich domain protein, U2-associated protein SR140, U2SURP, KIAA0332, SR140 |
| Entrez GeneID | 23350 |
| WB Predicted band size | 118.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SR140 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-62 amino acids from the N-terminal region of human SR140. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SR140 (N-term)抗体的参考文献示例(注：SR140相关文献可能较少，以下内容为模拟示例，实际文献需通过学术数据库验证)：
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1. **文献名称**: *"Characterization of SR140 (N-term) antibody in detecting nuclear receptor variants"*
**作者**: Smith A, et al.
**摘要**: 本研究验证了SR140 (N-term)抗体在识别核受体NR1D1 N端异构体中的特异性。通过Western blot和免疫荧光实验，证明该抗体在多种细胞系中能有效区分全长蛋白与截短变体，为研究核受体功能提供了可靠工具。
2. **文献名称**: *"SR140 antibody reveals circadian regulation of metabolic pathways"*
**作者**: Chen L, et al.
**摘要**: 利用SR140 (N-term)抗体，作者发现目标蛋白在小鼠肝脏中呈现昼夜节律性表达，并调控糖代谢相关基因。ChIP-seq分析进一步证实了该蛋白与代谢通路启动子区域的结合。
3. **文献名称**: *"Validation of SR140 as a biomarker in breast cancer progression"*
**作者**: Gupta R, et al.
**摘要**: 研究采用SR140 (N-term)抗体检测乳腺癌组织微阵列，发现蛋白表达水平与肿瘤分级和转移显著相关，提示其作为预后标志物的潜力。
4. **文献名称**: *"Technical evaluation of SR140 antibody for chromatin immunoprecipitation"*
**作者**: Kim H, et al.
**摘要**: 本文系统评估了SR140 (N-term)抗体在ChIP实验中的适用性，证明其能高效富集目标蛋白结合的染色质区域，并通过qPCR和测序验证了结果的可靠性。
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建议通过PubMed或Google Scholar以 **"SR140 antibody"**、**"NR1D1 antibody"**(假设SR140为核受体NR1D1别名)或结合抗体货号(如Abcam等厂商产品引用文献)进一步检索实际研究。
The SR140 (N-term) antibody is a polyclonal or monoclonal antibody specifically designed to target the N-terminal region of a protein of interest, though the exact identity of the target protein may vary depending on the specific product and manufacturer. Such antibodies are typically developed for use in molecular biology and biomedical research applications, including Western blotting (WB), immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP). The N-terminal region is often selected as an epitope due to its unique sequence, which can enhance antibody specificity and reduce cross-reactivity with unrelated proteins.
SR140 (N-term) antibodies are commonly employed to study protein expression, localization, post-translational modifications, or interactions in various experimental models. They may be validated using techniques like knockout/knockdown controls, peptide blocking assays, or recombinant protein overexpression to confirm binding specificity. These antibodies are particularly useful in research areas such as cancer biology, neuroscience, or cellular signaling, where understanding the role of specific proteins in pathways or disease mechanisms is critical.
Manufacturers typically provide details on host species, clonality, conjugation options, and species reactivity (e.g., human, mouse, rat). Researchers should verify compatibility with their experimental systems and optimize conditions (e.g., dilution, fixation methods) for reproducible results. Proper storage and handling are essential to maintain antibody stability and performance.
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