| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Na(+)/H(+) exchange regulatory cofactor NHE-RF4, NHERF-4, Intestinal and kidney-enriched PDZ protein, Natrium-phosphate cotransporter IIa C-terminal-associated protein 2, Na/Pi cotransporter C-terminal-associated protein 2, NaPi-Cap2, PDZ domain-containing protein 2, PDZ domain-containing protein 3, Sodium-hydrogen exchanger regulatory factor 4, PDZD3, IKEPP, NHERF4, PDZK2 |
| Entrez GeneID | 79849 |
| WB Predicted band size | 61.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PDZD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-285 amino acids from the Central region of human PDZD3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PDZD3抗体的3篇文献摘要信息，供参考：
1. **文献名称**：*PDZD3 modulates MAPK/ERK signaling in cancer cell proliferation*
**作者**：Li, X. et al.
**摘要**：研究揭示了PDZD3通过调控MAPK/ERK通路影响肿瘤细胞增殖，实验中利用特异性PDZD3抗体进行Western blot和免疫荧光，证实其在细胞核与细胞质中的定位差异。
2. **文献名称**：*Characterization of PDZD3 interactions with synaptic proteins in neuronal development*
**作者**：Wang, Y. et al.
**摘要**：该文献开发了兔源PDZD3多克隆抗体，通过免疫共沉淀(Co-IP)和质谱分析，发现PDZD3与突触后蛋白PSD-95存在相互作用，提示其在神经元突触形成中的潜在作用。
3. **文献名称**：*PDZD3 deficiency exacerbates oxidative stress-induced renal injury*
**作者**：Chen, J. et al.
**摘要**：研究利用PDZD3敲除小鼠模型及特异性抗体进行免疫组化，发现PDZD3缺失会增强肾脏氧化应激损伤，其机制可能与Nrf2通路抑制有关。
注：以上文献为示例性内容，实际引用时需核实真实数据库(如PubMed、Web of Science)中的具体研究。若需进一步协助定位真实文献，可提供更详细的研究背景。
The PDZD3 antibody is a tool used to study the PDZ domain-containing protein 3 (PDZD3), a member of the PDZ protein family characterized by conserved PDZ domains that mediate protein-protein interactions. PDZD3. also known as PDZK3 or IIP1. is involved in diverse cellular processes, including signal transduction, membrane trafficking, and maintaining cell polarity. It interacts with various partners, such as the tumor suppressor PTEN, regulating its stability and activity, which links PDZD3 to cancer pathways. Research suggests PDZD3 may play roles in prostate cancer, breast cancer, and neurological disorders, though its precise mechanisms remain under investigation.
Antibodies targeting PDZD3 are essential for detecting its expression, localization, and interaction networks in cells or tissues. They enable techniques like Western blotting, immunofluorescence, and immunohistochemistry, helping researchers map PDZD3's distribution in organs such as the brain, kidneys, and reproductive tissues. Studies using PDZD3 antibodies have revealed its potential as a biomarker or therapeutic target, particularly in cancers with dysregulated PTEN pathways. However, antibody specificity and validation remain critical, as cross-reactivity with other PDZ proteins can complicate interpretations. Overall, PDZD3 antibodies serve as vital reagents for unraveling the protein's biological and pathological significance.
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