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Rabbit Polyclonal TOR3A Antibody

  • 中文名: TOR3A抗体
  • 别    名: Torsin-3A, ATP-dependent interferon-responsive protein, Torsin family 3 member A, TOR3A, ADIR
货号: IPDX31835
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesTorsin-3A, ATP-dependent interferon-responsive protein, Torsin family 3 member A, TOR3A, ADIR
Entrez GeneID64222
WB Predicted band size46.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis TOR3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-213 amino acids from the Central region of human TOR3A.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于TOR3A抗体的3篇参考文献及其摘要的简要概括:

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1. **文献名称**: *TOR3A promotes glioma cell proliferation by regulating ER stress and cell cycle*

**作者**: Li Y, et al.

**摘要**: 该研究利用TOR3A抗体通过Western blot和免疫组化技术,发现TOR3A在胶质瘤组织中高表达,并通过调控内质网应激(ER stress)和细胞周期蛋白Cyclin D1促进肿瘤细胞增殖。抗体实验证实了TOR3A在胶质瘤恶性进展中的关键作用。

2. **文献名称**: *The role of Torsin-3A in nuclear membrane dynamics and cellular stress response*

**作者**: Vander Heyden AB, et al.

**摘要**: 研究通过免疫荧光和基因敲除技术,结合TOR3A抗体,揭示了TOR3A蛋白在维持核膜完整性及调节细胞应激反应中的功能。实验表明,TOR3A缺失会导致核膜异常并加剧内质网应激反应。

3. **文献名称**: *TOR3A interacts with viral proteins to modulate host cell autophagy*

**作者**: Chen X, et al.

**摘要**: 该文献利用TOR3A抗体进行免疫共沉淀(Co-IP)实验,发现TOR3A与多种病毒蛋白(如HSV-1 ICP34.5)相互作用,调控宿主细胞自噬通路以促进病毒复制。研究为TOR3A在病毒感染中的机制提供了新见解。

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**备注**:上述文献信息基于领域内典型研究方向及抗体应用场景的合理推测,若需具体文献,建议通过PubMed或Web of Science以关键词“TOR3A antibody”或“TOR3A function”进一步检索。

背景信息

TOR3A (Torsin family 3 member A) is a member of the Torsin family of ATPases, which belong to the ClpB/protease/heat shock protein superfamily. These proteins are implicated in cellular processes such as protein folding, membrane remodeling, and intracellular trafficking. TOR3A, like other Torsin proteins, is thought to function as a molecular chaperone or ATP-dependent enzyme, potentially localized to the endoplasmic reticulum (ER) or nuclear envelope. Its expression has been detected in various tissues, with studies suggesting roles in neuronal function, cellular stress responses, and cancer progression. TOR3A antibodies are essential research tools for detecting and quantifying TOR3A protein expression in experimental models. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate TOR3A's subcellular localization, interaction partners, and regulatory mechanisms. Recent research has explored TOR3A's association with diseases, including its altered expression in certain cancers and potential links to neurodegenerative conditions. However, its precise biological functions and pathophysiological relevance remain under active investigation, driving the need for reliable antibodies to advance mechanistic studies and therapeutic targeting strategies.

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