| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Myotonin-protein kinase, MT-PK, DM-kinase, DMK, DM1 protein kinase, DMPK, Myotonic dystrophy protein kinase, DMPK, DM1PK, MDPK |
| Entrez GeneID | 1760 |
| WB Predicted band size | 69.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This DMPK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-39 amino acids from the N-terminal region of human DMPK. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DMPK(N-term)抗体的参考文献示例(内容为虚构示例，建议通过学术数据库验证真实文献)：
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1. **文献名称**: "Characterization of a polyclonal antibody targeting the N-terminal region of human myotonic dystrophy protein kinase (DMPK)"
**作者**: Jansen et al.
**摘要**: 本研究开发并验证了一种针对DMPK蛋白N端区域的多克隆抗体。通过Western blot和免疫组化实验证实，该抗体能特异性识别HEK293细胞和小鼠骨骼肌中过表达的DMPK蛋白，为研究DMPK在强直性肌营养不良症(DM1)中的功能提供了工具。
2. **文献名称**: "DMPK expression profiling in human tissues using N-terminal specific antibodies"
**作者**: Smith et al.
**摘要**: 利用N端特异性DMPK抗体，作者系统分析了DMPK在人类心脏、脑和骨骼肌等组织中的表达分布。结果显示DMPK在心脏组织中高表达，且其亚型因组织差异呈现不同剪接变体，提示其在多器官病理中的作用。
3. **文献名称**: "Subcellular localization of DMPK isoforms revealed by N-terminal epitope tagging"
**作者**: Braun & Roberts
**摘要**: 通过构建N端标记的DMPK质粒并结合免疫荧光技术，研究发现DMPK主要定位于细胞核周边及胞质中，且其定位异常与CTG重复序列扩展导致的DM1病理特征相关。
4. **文献名称**: "The role of DMPK N-terminal phosphorylation in myotonic dystrophy type 1 pathogenesis"
**作者**: Wang et al.
**摘要**: 本研究利用N端特异性抗体探究DMPK磷酸化修饰对其功能的影响，发现磷酸化缺陷导致DMPK与肌肉分化相关蛋白的互作异常，可能参与DM1的肌肉萎缩和离子通道失调机制。
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**注意**：以上文献信息为示例性质，实际文献需通过PubMed、Web of Science等平台检索关键词如“DMPK antibody N-terminal”或“myotonic dystrophy kinase antibody”获取。
The DMPK (N-term) antibody is a specialized tool used to study the myotonic dystrophy protein kinase (DMPK), a key protein encoded by the *DMPK* gene. DMPK is primarily expressed in skeletal and cardiac muscles, as well as the brain, and plays roles in cellular signaling, ion channel regulation, and structural organization. Mutations in the *DMPK* gene, particularly CTG trinucleotide repeat expansions in the 3' untranslated region, are linked to myotonic dystrophy type 1 (DM1), a multisystemic disorder characterized by muscle weakness, cardiac defects, and neurological impairments.
The DMPK (N-term) antibody specifically targets the N-terminal region of the DMPK protein, enabling researchers to distinguish full-length or truncated isoforms of DMPK and assess their expression levels or localization. This antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate DMPK’s physiological functions and its dysregulation in DM1. Studies leveraging this antibody have revealed altered DMPK expression patterns, mislocalization in cells, and interactions with other proteins or RNA aggregates in DM1 pathology.
Additionally, the antibody aids in exploring therapeutic strategies targeting DMPK, such as antisense oligonucleotides or small molecules. Its specificity for the N-terminal domain makes it valuable for distinguishing DMPK from homologous kinases and validating experimental models of DM1. Overall, the DMPK (N-term) antibody is a critical reagent for advancing our understanding of myotonic dystrophy mechanisms and potential treatments.
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