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Rabbit Polyclonal PRAMEF14 Antibody

  • 中文名： PRAMEF14抗体
  • 别    名： PRAME family member 14, PRAMEF14
货号: IPDX31723
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPRAME family member 14, PRAMEF14
WB Predicted band size49.3kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PRAMEF14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213-241 amino acids from the Central region of human PRAMEF14.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于PRAMEF14抗体的3篇模拟参考文献示例(实际文献需通过学术数据库检索确认)：

1. **文献名称**: "Characterization of PRAMEF14 as a novel cancer-testis antigen in melanoma"

**作者**: Li, X., Wang, Y., & Zhang, Q.

**摘要**: 本研究鉴定了PRAMEF14蛋白在黑色素瘤细胞中的特异性表达，开发了针对其N端表位的单克隆抗体，证实其在肿瘤组织中的高表达与患者预后不良相关。

2. **文献名称**: "PRAMEF14 antibody-based detection of epigenetic regulators in lung adenocarcinoma"

**作者**: Gupta, S., et al.

**摘要**: 文章报道了一种高灵敏度的PRAMEF14多克隆抗体，通过免疫组化分析揭示了其在肺腺癌中与DNA甲基化调控因子的共定位，提示其潜在表观遗传功能。

3. **文献名称**: "Development of a rabbit monoclonal antibody for PRAMEF14 and its application in chromatin immunoprecipitation"

**作者**: Tanaka, K., et al.

**摘要**: 研究团队利用重组PRAMEF14蛋白免疫制备了兔源单克隆抗体，成功应用于ChIP-seq技术，揭示了PRAMEF14在干细胞分化过程中与特定基因启动子的结合模式。

**备注**：以上文献为模拟示例，实际研究中建议通过PubMed或Google Scholar以关键词"PRAMEF14 antibody"+"melanoma/cancer/epigenetics"检索真实文献，并优先选择近3年发表的论文。

背景信息

The PRAMEF14 antibody is associated with the study of PRAMEF14 (Prame Family Member 14), a protein encoded by a gene belonging to the PRAME (Preferentially Expressed Antigen in Melanoma) family. This family comprises cancer-testis antigens (CTAs) typically expressed in germline cells but aberrantly reactivated in various cancers, making them potential biomarkers and therapeutic targets. PRAMEF14. located on human chromosome 1p36. shares structural features with other PRAME family members, including a conserved PRAME-like domain implicated in protein-protein interactions and epigenetic regulation. While its precise biological function remains under investigation, PRAMEF14 is hypothesized to play roles in cell proliferation, apoptosis, or immune evasion, similar to other CTAs. Antibodies targeting PRAMEF14 are primarily used in research to detect its expression and localization in tissues, particularly in cancer studies. Overexpression of PRAMEF14 has been observed in malignancies such as melanoma, lung cancer, and leukemia, suggesting diagnostic or prognostic relevance. However, its low expression in normal tissues and variable immunogenicity pose challenges for therapeutic applications. Current efforts focus on characterizing its molecular mechanisms, interaction networks, and potential as a target for immunotherapy or liquid biopsy-based cancer detection. Further validation is required to establish its clinical utility.

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