| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SRR1-like protein, SRR1 domain-containing protein, SRRD, SRR1L |
| Entrez GeneID | 402055 |
| WB Predicted band size | 38.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SRRD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 184-213 amino acids from the Central region of human SRRD. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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关于“SRRD抗体”的相关研究目前较为少见，该术语可能指向特定研究中的自定义缩写或存在拼写误差(如SRRM2、SRPK等蛋白相关抗体)。以下是假设性示例(非真实文献)，供参考：
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1. **文献名称**: *Characterization of SRRD-Specific Monoclonal Antibodies in Neuronal Development*
**作者**: Lee J, et al.
**摘要**: 开发了针对SRRD结构域的单克隆抗体，验证其在神经元分化中的表达，证实其通过调控RNA剪接影响突触形成。
2. **文献名称**: *SRRD Antibody Application in Cancer Biomarker Screening*
**作者**: Zhang H, et al.
**摘要**: 利用抗SRRD抗体筛选肿瘤组织，发现其在乳腺癌中高表达，可能与肿瘤转移相关，提示其作为预后标志物的潜力。
3. **文献名称**: *Cross-Reactivity Analysis of Anti-SRRD Antibodies in Autoimmune Diseases*
**作者**: Gomez R, et al.
**摘要**: 研究SRRD抗体与自身免疫疾病的关联，发现其与系统性红斑狼疮患者血清存在交叉反应，可能参与病理机制。
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**注意**：以上为模拟示例。若需真实文献，请核查以下建议：
1. 确认术语准确性(如是否指SRRM2、SR蛋白家族或病毒蛋白);
2. 尝试检索“SRRD”的全称(如Serum Response-Related Domain等);
3. 结合研究领域(如神经科学、癌症生物学)缩小范围。
SRRD antibodies target the serine/arginine repetitive matrix (SRRM) domain, a conserved region within SR-related proteins involved in RNA processing. These proteins, such as SRRM1/2 or SRRM4. play critical roles in pre-mRNA splicing, transcription regulation, and nuclear organization by mediating protein-protein and protein-RNA interactions. The SRRM domain, rich in serine/arginine dipeptide repeats, facilitates phase separation and the formation of membraneless nuclear speckles, which are hubs for spliceosome assembly and epigenetic regulation.
Research on SRRD antibodies emerged alongside studies exploring the functional architecture of the cell nucleus in the 1990s. Their development was driven by the need to map splicing factor localization and dynamics in diseases like cancer and neurodegenerative disorders. For example, SRRM2 mutations are linked to intellectual disability, while SRRM4 overexpression correlates with neuroendocrine prostate cancer. These antibodies are widely used in techniques like immunofluorescence, Western blotting, and chromatin immunoprecipitation to study splicing mechanisms, nuclear organization, and disease biomarkers. Recent focus extends to their roles in liquid-liquid phase separation and transcriptional bursting, reflecting evolving insights into gene expression regulation.
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