| WB | 1/4000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serpin H1, 47 kDa heat shock protein, Collagen-binding protein, Colligin, GP46, Serpinh1, Cbp1, Hsp47 |
| Entrez GeneID | 29345 |
| WB Predicted band size | 46.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Rat Serpinh1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 222-251 amino acids from the Central region of rat Serpinh1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于研究领域常见的文献主题和结构生成的示例性参考文献(请注意部分信息为模拟示例，建议通过学术数据库核实具体文献)：
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1. **文献名称**: "Role of Serpinh1 in Collagen Biosynthesis during Rat Liver Fibrosis"
**作者**: Tanaka, K. et al.
**摘要**: 研究通过Western blot和免疫组化分析了大鼠肝纤维化模型中Serpinh1(HSP47)的表达变化，使用特异性抗体验证其与胶原共定位，表明Serpinh1在纤维化进展中的调控作用。
2. **文献名称**: "Expression Profiling of HSP47 in Diabetic Nephropathy Rat Models"
**作者**: Zhang, L. & Chen, W.
**摘要**: 该文献利用抗大鼠Serpinh1抗体进行肾脏组织染色和蛋白质分析，发现糖尿病肾病模型中HSP47表达升高，提示其可能作为肾间质纤维化的生物标志物。
3. **文献名称**: "Serpinh1 Antibody-Based Detection of Cardiac Fibrosis in Hypertensive Rats"
**作者**: Müller, R. et al.
**摘要**: 研究通过免疫荧光和ELISA技术，结合特异性抗大鼠Serpinh1抗体，证实高血压诱导的心肌纤维化与HSP47表达呈正相关，为靶向治疗提供依据。
4. **文献名称**: "Inhibition of HSP47 Attenuates Pulmonary Fibrosis in a Rat Model"
**作者**: Sato, Y. et al.
**摘要**: 通过siRNA沉默Serpinh1基因并利用抗体检测胶原沉积，证明抑制HSP47可显著减轻博来霉素诱导的大鼠肺纤维化程度。
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**提示**：实际文献需通过PubMed或Google Scholar检索关键词(如 "Rat Serpinh1 antibody"、"HSP47 Rat fibrosis")获取。部分抗体厂商(如Abcam、Santa Cruz)的技术手册也可能引用相关应用文献。
The rat Serpinh1 antibody is a tool used to detect Serpinh1. a protein encoded by the Serpinh1 gene, which belongs to the serpin family of serine protease inhibitors. Serpinh1. also known as heat shock protein 47 (HSP47), functions as a molecular chaperone critical for collagen biosynthesis. It binds to procollagen in the endoplasmic reticulum, ensuring proper folding and stability, and is essential for maintaining extracellular matrix integrity. Dysregulation of Serpinh1 is linked to fibrosis, tissue scarring, and diseases like osteogenesis imperfecta.
In research, the rat-specific Serpinh1 antibody enables the study of this protein's expression, localization, and role in rat models, particularly in fibrosis, wound healing, and connective tissue disorders. It is widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess Serpinh1 levels in tissues like liver, lung, or skin under pathological conditions. The antibody’s specificity for rat samples ensures minimal cross-reactivity with homologs from other species.
Developed using immunogens derived from rat Serpinh1. these antibodies (polyclonal or monoclonal) are validated for sensitivity and reliability. Their application aids in understanding collagen-related mechanisms and evaluating therapeutic interventions targeting fibrotic pathways in preclinical rodent studies.
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