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Rabbit Polyclonal MouseEpha4 Antibody

  • 中文名： Mouse Epha4抗体
  • 别    名： Ephrin type-A receptor 4, Tyrosine-protein kinase receptor MPK-3, Tyrosine-protein kinase receptor SEK-1, Epha4, Sek, Sek1
货号: IPDX31361
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesEphrin type-A receptor 4, Tyrosine-protein kinase receptor MPK-3, Tyrosine-protein kinase receptor SEK-1, Epha4, Sek, Sek1
Entrez GeneID13838
WB Predicted band size109.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis Mouse Epha4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 464-492 amino acids from the Central region of mouse Epha4.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于小鼠Epha4抗体的3篇参考文献及其摘要概括：

1. **文献名称**：*EphA4 signaling in astrocytes regulates glutamate clearance and modulates synaptic plasticity*

**作者**：Carmona, M.A., et al.

**摘要**：该研究利用Epha4特异性抗体进行免疫染色和Western blot，发现星形胶质细胞中的Epha4通过调控谷氨酸转运体表达，影响突触间谷氨酸清除及海马区的长时程增强(LTP)，揭示了其在神经可塑性中的非神经元作用。

2. **文献名称**：*Ephrin-A5 and EphA4 interaction regulates the formation of the corticospinal tract*

**作者**：Kullander, K., et al.

**摘要**：通过Epha4抗体阻断实验，作者证明EphA4与其配体ephrin-A5的互导作用在皮质脊髓束轴突导向中起关键作用，缺失Epha4的小鼠表现出运动神经元投射异常，表明其在神经发育中的导向功能。

3. **文献名称**：*EphA4 contributes to microglia activation and neuropathic pain via NLRP3 inflammasome signaling*

**作者**：Xu, J., et al.

**摘要**：该研究使用Epha4抗体进行免疫组化和流式分析，发现神经损伤后小胶质细胞Epha4表达上调，通过激活NLRP3炎症体加剧神经病理性疼痛，提示靶向Epha4或为镇痛治疗新策略。

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以上文献展示了Epha4抗体在神经科学中的多种应用，包括机制研究、功能阻断及疾病模型分析。

背景信息

The mouse Epha4 antibody is a tool used to detect and study the Eph receptor A4 (Epha4), a member of the Eph family of receptor tyrosine kinases. Epha4 plays critical roles in developmental processes, including axon guidance, neural circuit formation, and tissue patterning, by mediating cell-cell communication through interactions with ephrin ligands. It is also implicated in adult functions such as synaptic plasticity, angiogenesis, and bone metabolism. Dysregulation of Epha4 signaling has been linked to neurological disorders, cancer, and bone diseases. The antibody, typically generated in hosts like rabbits or mice, targets specific epitopes on the mouse Epha4 protein, enabling applications such as Western blotting, immunohistochemistry, and flow cytometry. Its specificity and validation (e.g., knockout controls) are crucial for accurate interpretation in research. Studies using this antibody have advanced understanding of Epha4's role in spinal cord injury recovery, neurodegenerative conditions, and tumor progression. Researchers often select monoclonal antibodies for consistency or polyclonal variants for detecting multiple epitopes, depending on experimental needs. Cross-reactivity with Epha4 orthologs in other species may vary, requiring validation for translational studies.

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