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Rabbit Polyclonal DHFRL1 Antibody

  • 中文名: DHFRL1抗体
  • 别    名: Dihydrofolate reductase, mitochondrial, Dihydrofolate reductase-like protein 1, DHFRL1, DHFRP4
货号: IPDX31275
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

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参考文献

以下是关于DHFRL1抗体的3篇参考文献示例(注:DHFRL1相关研究较少,以下内容为模拟文献,供参考):

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1. **文献名称**: *Characterization of DHFRL1-Specific Monoclonal Antibodies for Functional Studies*

**作者**: Smith A, et al.

**摘要**: 本研究成功制备并验证了针对人源DHFRL1蛋白的单克隆抗体,通过免疫印迹和免疫组化证实其特异性,并用于探究DHFRL1在细胞线粒体中的叶酸代谢调控功能。

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2. **文献名称**: *DHFRL1 Expression in Cancer: A Novel Biomarker Identified by Immunohistochemical Analysis*

**作者**: Chen L, et al.

**摘要**: 利用商业化DHFRL1抗体对多种肿瘤组织进行检测,发现DHFRL1在结直肠癌中显著高表达,提示其可能作为潜在治疗靶点或预后标志物。

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3. **文献名称**: *Development of a Polyclonal Antibody Against DHFRL1 and Its Application in Neurological Disorders*

**作者**: Gupta R, et al.

**摘要**: 研究开发了兔源多克隆DHFRL1抗体,验证其在脑组织中的结合特异性,并发现阿尔茨海默病患者脑脊液中DHFRL1水平异常,可能与神经退行性病变相关。

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**提示**:实际研究中DHFRL1抗体相关文献较少,建议通过PubMed或Google Scholar以“DHFRL1 antibody”或“DHFR-like 1”为关键词检索最新进展。部分研究可能涉及DHFRL1基因功能而非抗体开发,需结合需求筛选。

背景信息

The DHFRL1 antibody is a research tool designed to target dihydrofolate reductase-like 1 (DHFRL1), a lesser-studied enzyme within the dihydrofolate reductase (DHFR) family. DHFR enzymes are critical in folate metabolism, catalyzing the reduction of dihydrofolate to tetrahydrofolate (THF), a cofactor essential for nucleotide synthesis and cellular proliferation. While the canonical DHFR is well-characterized in DNA synthesis and a target for antifolate drugs (e.g., methotrexate), DHFRL1 remains poorly understood. It shares sequence homology with DHFR but exhibits distinct tissue expression patterns, suggesting divergent biological roles. Studies suggest DHFRL1 may function in mitochondria, potentially influencing folate metabolism in organellar compartments or under specific physiological conditions. The DHFRL1 antibody is primarily used in basic research to investigate its localization, expression levels, and interactions in cellular models or tissues, particularly in contexts like cancer, mitochondrial disorders, or developmental processes. Current challenges include clarifying its enzymatic activity, regulatory mechanisms, and relevance to human diseases. Commercial antibodies are typically validated for applications such as Western blotting, immunohistochemistry, or immunofluorescence, aiding in elucidating DHFRL1's role in cellular pathways beyond classical folate metabolism.

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