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Rabbit Polyclonal PROSC Antibody

  • 中文名: PROSC抗体
  • 别    名: Proline synthase co-transcribed bacterial homolog protein, PROSC
货号: IPDX31203
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProline synthase co-transcribed bacterial homolog protein, PROSC
Entrez GeneID11212
WB Predicted band size30.3kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PROSC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-260 amino acids from the C-terminal region of human PROSC.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于PROSC抗体的3篇模拟参考文献示例(注:以下文献为虚构示例,仅用于格式演示):

1. **文献名称**: "PROSC Antibody Development for Targeted Prostate Cancer Therapy"

**作者**: Smith A, et al.

**摘要**: 研究开发了高特异性PROSC单克隆抗体,用于检测前列腺癌细胞中PROSC蛋白的过表达,证实其可作为潜在治疗靶点。

2. **文献名称**: "Role of PROSC in Neural Development: Insights from Antibody-Based Knockdown Studies"

**作者**: Chen L, et al.

**摘要**: 利用PROSC抗体进行功能阻断实验,发现PROSC蛋白在小鼠大脑皮层神经元分化中调控Wnt信号通路。

3. **文献名称**: "Validation of a Novel PROSC Antibody for Immunohistochemical Staining in Solid Tumors"

**作者**: Gupta R, et al.

**摘要**: 验证了一种新型兔源多克隆PROSC抗体的灵敏度和特异性,成功应用于乳腺癌组织样本的蛋白定位及预后分析。

如需真实文献,建议通过PubMed或Google Scholar搜索关键词“PROSC antibody”或“PROSC protein function”获取最新研究。

背景信息

The PROSC antibody targets PROSC (prospero-related homeobox 1 homolog), a protein encoded by the PROSC gene in humans. Originally identified in *Drosophila*, where it regulates neuronal development, PROSC is implicated in vitamin B6 (pyridoxal 5'-phosphate, PLP) metabolism, facilitating PLP homeostasis by binding and stabilizing intracellular PLP. Dysregulation of PROSC is linked to vitamin B6-dependent epilepsy and neurodevelopmental disorders. Antibodies against PROSC are essential tools for studying its expression, localization, and interaction partners in cellular and tissue contexts. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding research into its role in neurological health and disease. Additionally, PROSC antibodies contribute to elucidating molecular mechanisms underlying PLP-related metabolic pathways and potential therapeutic targets for B6-responsive conditions. Commercial PROSC antibodies are typically validated in model organisms and human samples, with applications spanning basic research and clinical diagnostics.

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