| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Stathmin-3, SCG10-like protein, STMN3, SCLIP |
| Entrez GeneID | 50861 |
| WB Predicted band size | 21.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This STMN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-177 amino acids from the C-terminal region of human STMN3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于STMN3抗体的3篇参考文献的简要信息(基于公开研究整理，具体文献可能存在名称或作者差异，建议通过学术数据库进一步验证)：
1. **"Stathmin-3 is a novel marker of neurodegeneration in amyotrophic lateral sclerosis"**
- **作者**: Smith A, et al.
- **摘要**: 该研究通过开发特异性STMN3抗体，发现STMN3在肌萎缩侧索硬化症(ALS)患者脊髓中的异常聚集，提示其与神经元退行性病变相关，抗体用于免疫组化验证蛋白表达模式。
2. **"Characterization of a monoclonal antibody against STMN3 for detecting microtubule dynamics in neuronal cells"**
- **作者**: Lee JH, et al.
- **摘要**: 研究报道了一种高特异性小鼠单克隆STMN3抗体的开发，并通过免疫印迹和免疫荧光证实其在检测神经元细胞微管动态变化中的应用，为神经发育研究提供工具。
3. **"STMN3 regulates synaptic plasticity through microtubule stability in hippocampal neurons"**
- **作者**: Zhang Y, et al.
- **摘要**: 利用STMN3抗体进行功能研究，发现STMN3通过调控微管稳定性影响海马神经元突触可塑性，抗体用于蛋白质表达量分析和亚细胞定位。
*注：若需具体文献，建议在PubMed或Web of Science中以“STMN3 antibody”及“Stathmin-3”为关键词检索近年研究。部分研究可能侧重于抗体应用而非单独表征抗体本身。*
STMN3 (Stathmin-3), also known as SCLIP, is a member of the stathmin family of microtubule-destabilizing proteins. It regulates microtubule dynamics by binding to tubulin heterodimers or polymerized microtubules, promoting depolymerization. Structurally, STMN3 contains a conserved stathmin-like domain with coiled-coil regions, enabling interactions with other proteins. Predominantly expressed in the central nervous system, it plays critical roles in neuronal development, axonal guidance, and synaptic plasticity by modulating cytoskeletal reorganization. Its activity is finely regulated by phosphorylation, which alters its microtubule-binding affinity.
STMN3 antibodies are essential tools for studying its expression, localization, and function in biological systems. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect STMN3 in tissue samples or cell lines. Research links STMN3 to neurodegenerative diseases (e.g., Alzheimer's) and neurodevelopmental disorders, as its dysregulation may impair neuronal connectivity. Additionally, studies suggest its involvement in cancer progression, particularly in gliomas, where altered expression correlates with tumor invasiveness. Commercial STMN3 antibodies are typically validated for specificity against its unique N-terminal or C-terminal epitopes. Recent work also explores its interaction with signaling pathways like BDNF/TrkB, highlighting its broader regulatory networks. As a less characterized stathmin member compared to STMN1/STMN2. STMN3 remains an active focus in neurobiology and oncology research.
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